Seroatlas · Human Serome Atlas

WDR82

WD repeat-containing protein 82

Also known as: MST107, MSTP107, PRO2730, PRO34047, SWD2, TMEM113, WDR82_HUMAN, WDR82A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UXN9
Gene
WDR82
Ensembl
ENSG00000164091
Chromosome
3
Canonical length
313 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli rim

OverviewNCBI Gene

TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q6UXN9|WDR82
     1  MKLTDSVLRS FRVAKVFREN SDKINCFDFS PNGETVISSS DDDSIVLYDC QEGKPKRTLY
    61  SKKYGVDLIR YTHAANTVVY SSNKIDDTIR YLSLHDNKYI RYFPGHSKRV VALSMSPVDD
   121  TFISGSLDKT IRLWDLRSPN CQGLMHLQGK PVCSFDPEGL IFAAGVNSEM VKLYDLRSFD
   181  KGPFATFKMQ YDRTCEWTGL KFSNDGKLIL ISTNGSFIRL IDAFKGVVMH TFGGYANSKA
   241  VTLEASFTPD SQFIMIGSED GKIHVWNGES GIKVAVLDGK HTGPITCLQF NPKFMTFASA
   301  CSNMAFWLPT IDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR82 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
68 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 68 nTPM
  • tongue: 63 nTPM
  • skeletal muscle: 62 nTPM
  • cerebellum: 58 nTPM
  • tonsil: 57 nTPM
  • lymph node: 54 nTPM

Single-cell type

  • late spermatids: 310 nCPM
  • neutrophils: 114 nCPM
  • endometrial luminal cells: 114 nCPM
  • endometrial glandular cells: 108 nCPM
  • neutrophil progenitors: 91 nCPM
  • retinal pigment epithelial cells: 90 nCPM

Immune cell

  • MAIT T-cell: 19 nTPM
  • naive CD8 T-cell: 16 nTPM
  • naive CD4 T-cell: 16 nTPM
  • gdT-cell: 15 nTPM
  • memory CD8 T-cell: 15 nTPM
  • neutrophil: 14 nTPM

Brain region

  • hypothalamus: 77 nTPM
  • cerebellum: 67 nTPM
  • cerebral cortex: 66 nTPM
  • basal ganglia: 64 nTPM
  • choroid plexus: 64 nTPM
  • spinal cord: 60 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR82.

Disease | ImmuneIEDB

Conditions an epitope on WDR82 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.89
gnomAD missense Z
3.29
DepMap mean gene effect
-1.52
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR82 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR82 as an antibody target. Whether an autoantibody or antibody against WDR82 could matter depends on whether native WDR82 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR82 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR82 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR82. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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