Seroatlas · Human Serome Atlas

RBBP4

Histone-binding protein RBBP4

Also known as: lin-53, NURF55, RbAp48, RBBP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q09028
Gene
RBBP4
Ensembl
ENSG00000162521
Chromosome
1
Canonical length
425 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q09028|RBBP4
     1  MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL PDVTRPEGKD
    61  FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS EKGEFGGFGS VSGKIEIEIK
   121  INHEGEVNRA RYMPQNPCII ATKTPSSDVL VFDYTKHPSK PDPSGECNPD LRLRGHQKEG
   181  YGLSWNPNLS GHLLSASDDH TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE
   241  SLFGSVADDQ KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL
   301  WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI GEEQSPEDAE
   361  DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ VWQMAENIYN DEDPEGSVDP
   421  EGQGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBBP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
86 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 86 nTPM
  • testis: 71 nTPM
  • lymph node: 59 nTPM
  • thymus: 54 nTPM
  • retina: 52 nTPM
  • rectum: 43 nTPM

Single-cell type

  • erythrocyte progenitors: 253 nCPM
  • oocytes: 203 nCPM
  • sertoli cells: 190 nCPM
  • megakaryocyte progenitors: 171 nCPM
  • plasma cells: 158 nCPM
  • early primary spermatocytes: 157 nCPM

Immune cell

  • total PBMC: 152 nTPM
  • myeloid DC: 115 nTPM
  • classical monocyte: 100 nTPM
  • intermediate monocyte: 100 nTPM
  • plasmacytoid DC: 96 nTPM
  • non-classical monocyte: 96 nTPM

Brain region

  • white matter: 68 nTPM
  • cerebellum: 58 nTPM
  • spinal cord: 55 nTPM
  • medulla oblongata: 55 nTPM
  • hypothalamus: 54 nTPM
  • thalamus: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
4.63
DepMap mean gene effect
-1.19
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBBP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBBP4 as an antibody target. Whether an autoantibody or antibody against RBBP4 could matter depends on whether native RBBP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBBP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBBP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBBP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...