Seroatlas · Human Serome Atlas

WDR88

WD repeat-containing protein 88

Also known as: PQWD, WDR88_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMY6
Gene: WDR88
Ensembl: ENSG00000166359
Chromosome: 19
Canonical length: 472 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

No narrative summary is available for WDR88 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>Q6ZMY6|WDR88
     1  MASPPRCSPT AHDRECKLPP PSAPASEYCP GKLSWGTMAR ALGRFKLSIP HTHLLATLDP
    61  LALDREPPPH LLPEKHQVPE KLIWGDQDPL SKIPFKILSG HEHAVSTCHF CVDDTKLLSG
   121  SYDCTVKLWD PVDGSVVRDF EHRPKAPVVE CSITGDSSRV IAASYDKTVR AWDLETGKLL
   181  WKVRYDTFIV SCKFSPDGKY VVSGFDVDHG ICIMDAENIT TVSVIKDHHT RSITSCCFDP
   241  DSQRVASVSL DRCIKIWDVT SQATLLTITK AHSNAISNCC FTFSGHFLCT SSWDKNLKIW
   301  NVHTGEFRNC GACVTLMQGH EGSVSSCHFA RDSSFLISGG FDRTVAIWDV AEGYRKLSLK
   361  GHNDWVMDVA ISNNKKWILS ASKDRTMRLW NIEEIDEIPL VIKYKKAVGL KLKQCERCDR
   421  PFSIFKSDTS SEMFTQCVFC RIDTRGLPAD TSSSSSSSER ENSPPPRGSK DD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR88 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 8.6 nTPM

Expression across tissuesHPA

Tissue

testis: 8.6 nTPM
retina: 1.4 nTPM
lymph node: 1.1 nTPM
cerebral cortex: 0.9 nTPM
thyroid gland: 0.9 nTPM
appendix: 0.8 nTPM

Single-cell type

late primary spermatocytes: 64 nCPM
cardiomyocytes: 32 nCPM
early spermatids: 27 nCPM
cone photoreceptor cells: 21 nCPM
late spermatids: 21 nCPM
retinal horizontal cells: 18 nCPM

Immune cell

NK-cell: 0.5 nTPM
gdT-cell: 0.2 nTPM
intermediate monocyte: 0.2 nTPM
MAIT T-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

basal ganglia: 4.3 nTPM
cerebellum: 4.3 nTPM
cerebral cortex: 4.1 nTPM
hippocampal formation: 3.6 nTPM
amygdala: 3.3 nTPM
thalamus: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.96
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR88 as an antibody target. Whether an autoantibody or antibody against WDR88 could matter depends on whether native WDR88 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR88 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR88 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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