Seroatlas · Human Serome Atlas

WDR38

WD repeat-containing protein 38

Also known as: WDR38_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JTN6
Gene: WDR38
Ensembl: ENSG00000136918
Chromosome: 9
Canonical length: 314 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be part of transferase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q5JTN6|WDR38
     1  MNSGVPATLA VRRVKFFGQH GGEVNSSAFS PDGQMLLTGS EDGCVYGWET RSGQLLWRLG
    61  GHTGPVKFCR FSPDGHLFAS ASCDCTVRLW DVARAKCLRV LKGHQRSVET VSFSPDSRQL
   121  ASGGWDKRVM LWDVQSGQML RLLVGHRDSI QSSDFSPTVN CLATGSWDST VHIWDLRMVT
   181  PAVSHQALEG HSANISCLCY SASGLLASGS WDKTIHIWKP TTSSLLIQLK GHVTWVKSIA
   241  FSPDELWLAS AGYSRMVKVW DCNTGKCLET LKGVLDVAHT CAFTPDGKIL VSGAADQTRR
   301  QISRTSKSPR DPQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 73 nTPM
choroid plexus: 43 nTPM
testis: 7.3 nTPM
lung: 5.2 nTPM
hypothalamus: 3.9 nTPM
hippocampal formation: 3.5 nTPM

Single-cell type

respiratory ciliated cells: 284 nCPM
fallopian tube ciliated cells: 223 nCPM
late spermatids: 175 nCPM
epididymal efferent duct ciliated cells: 163 nCPM
endometrial ciliated cells: 100 nCPM
ependymal cells: 35 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 32 nTPM
midbrain: 19 nTPM
medulla oblongata: 18 nTPM
spinal cord: 14 nTPM
hypothalamus: 7.7 nTPM
pons: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

hematopoietic progenitor cell differentiation

Cellular components

transferase complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR38 as an antibody target. Whether an autoantibody or antibody against WDR38 could matter depends on whether native WDR38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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