Seroatlas · Human Serome Atlas

GNB1

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Also known as: GBB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62873
Gene
GNB1
Ensembl
ENSG00000078369
Chromosome
1
Canonical length
340 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins, Transporters
Subcellular location
Golgi apparatus,Plasma membrane

OverviewNCBI Gene

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>P62873|GNB1
     1  MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA
    61  MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI
   121  CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLDDNQIVTS SGDTTCALWD IETGQQTTTF
   181  TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA
   241  FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL
   301  KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
2,147 nTPM

Expression across tissuesHPA

Tissue

  • retina: 2,147 nTPM
  • cerebral cortex: 311 nTPM
  • amygdala: 222 nTPM
  • basal ganglia: 207 nTPM
  • small intestine: 198 nTPM
  • cerebellum: 196 nTPM

Single-cell type

  • rod photoreceptor cells: 2,098 nCPM
  • neutrophils: 1,581 nCPM
  • neutrophil progenitors: 618 nCPM
  • monocytes: 605 nCPM
  • monocyte progenitors: 439 nCPM
  • thymocytes: 428 nCPM

Immune cell

  • plasmacytoid DC: 23 nTPM
  • neutrophil: 22 nTPM
  • eosinophil: 20 nTPM
  • non-classical monocyte: 16 nTPM
  • intermediate monocyte: 16 nTPM
  • classical monocyte: 14 nTPM

Brain region

  • cerebral cortex: 504 nTPM
  • basal ganglia: 441 nTPM
  • white matter: 436 nTPM
  • hypothalamus: 389 nTPM
  • pons: 385 nTPM
  • hippocampal formation: 380 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GNB1.

Disease | AllUniProt

Conditions GNB1 is implicated in, by any mechanism.

  • Intellectual developmental disorder, autosomal dominant 42 (MRD42) MIM:616973

Disease | GeneticClinVar

59 pathogenic / likely-pathogenic of 395 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
3.83
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNB1 as an antibody target. Whether an autoantibody or antibody against GNB1 could matter depends on whether native GNB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNB1 is annotated at the cell surface, where native GNB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GNB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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