Seroatlas · Human Serome Atlas

CORO7

Coronin-7

Also known as: CORO7_HUMAN, FLJ22021, POD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57737
Gene: CORO7
Ensembl: ENSG00000262246
Chromosome: 16
Canonical length: 925 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

925 residues, UniProt reviewed canonical sequence.

>P57737|CORO7
     1  MNRFRVSKFR HTEARPPRRE SWISDIRAGT APSCRNHIKS SCSLIAFNSD RPGVLGIVPL
    61  QGQGEDKRRV AHLGCHSDLV TDLDFSPFDD FLLATGSADR TVKLWRLPGP GQALPSAPGV
   121  VLGPEDLPVE VLQFHPTSDG ILVSAAGTTV KVWDAAKQQP LTELAAHGDL VQSAVWSRDG
   181  ALVGTACKDK QLRIFDPRTK PRASQSTQAH ENSRDSRLAW MGTWEHLVST GFNQMREREV
   241  KLWDTRFFSS ALASLTLDTS LGCLVPLLDP DSGLLVLAGK GERQLYCYEV VPQQPALSPV
   301  TQCVLESVLR GAALVPRQAL AVMSCEVLRV LQLSDTAIVP IGYHVPRKAV EFHEDLFPDT
   361  AGCVPATDPH SWWAGDNQQV QKVSLNPACR PHPSFTSCLV PPAEPLPDTA QPAVMETPVG
   421  DADASEGFSS PPSSLTSPST PSSLGPSLSS TSGIGTSPSL RSLQSLLGPS SKFRHAQGTV
   481  LHRDSHITNL KGLNLTTPGE SDGFCANKLR VAVPLLSSGG QVAVLELRKP GRLPDTALPT
   541  LQNGAAVTDL AWDPFDPHRL AVAGEDARIR LWRVPAEGLE EVLTTPETVL TGHTEKICSL
   601  RFHPLAANVL ASSSYDLTVR IWDLQAGADR LKLQGHQDQI FSLAWSPDGQ QLATVCKDGR
   661  VRVYRPRSGP EPLQEGPGPK GGRGARIVWV CDGRCLLVSG FDSQSERQLL LYEAEALAGG
   721  PLAVLGLDVA PSTLLPSYDP DTGLVLLTGK GDTRVFLYEL LPESPFFLEC NSFTSPDPHK
   781  GLVLLPKTEC DVREVELMRC LRLRQSSLEP VAFRLPRVRK EFFQDDVFPD TAVIWEPVLS
   841  AEAWLQGANG QPWLLSLQPP DMSPVSQAPR EAPARRAPSS AQYLEEKSDQ QKKEELLNAM
   901  VAKLGNREDP LPQDSFEGVD EDEWD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CORO7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 66 nTPM
spleen: 57 nTPM
small intestine: 31 nTPM
testis: 28 nTPM
lung: 28 nTPM
basal ganglia: 24 nTPM

Single-cell type

microglia: 45 nCPM
oligodendrocytes: 41 nCPM
oligodendrocyte progenitor cells: 23 nCPM
brain excitatory neurons: 16 nCPM
other brain neurons: 15 nCPM
brain inhibitory neurons: 14 nCPM

Immune cell

eosinophil: 31 nTPM
intermediate monocyte: 24 nTPM
non-classical monocyte: 20 nTPM
neutrophil: 17 nTPM
basophil: 17 nTPM
classical monocyte: 17 nTPM

Brain region

white matter: 46 nTPM
medulla oblongata: 32 nTPM
basal ganglia: 31 nTPM
cerebral cortex: 31 nTPM
thalamus: 29 nTPM
pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CORO7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KLHL20

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CORO7 as an antibody target. Whether an autoantibody or antibody against CORO7 could matter depends on whether native CORO7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CORO7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CORO7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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