Seroatlas · Human Serome Atlas

WDFY1

WD repeat and FYVE domain-containing protein 1

Also known as: FENS-1, KIAA1435, WDF1, WDFY1_HUMAN, ZFYVE17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWB7
Gene: WDFY1
Ensembl: ENSG00000085449
Chromosome: 2
Canonical length: 410 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>Q8IWB7|WDFY1
     1  MAAEIHSRPQ SSRPVLLSKI EGHQDAVTAA LLIPKEDGVI TASEDRTIRV WLKRDSGQYW
    61  PSIYHTMASP CSAMAYHHDS RRIFVGQDNG AVMEFHVSED FNKMNFIKTY PAHQNRVSAI
   121  IFSLATEWVI STGHDKCVSW MCTRSGNMLG RHFFTSWASC LQYDFDTQYA FVGDYSGQIT
   181  LLKLEQNTCS VITTLKGHEG SVACLWWDPI QRLLFSGASD NSIIMWDIGG RKGRTLLLQG
   241  HHDKVQSLCY LQLTRQLVSC SSDGGIAVWN MDVSREEAPQ WLESDSCQKC EQPFFWNIKQ
   301  MWDTKTLGLR QHHCRKCGQA VCGKCSSKRS SYPVMGFEFQ VRVCDSCYDS IKDEDRTSLA
   361  TFHEGKHNIS HMSMDIARGL MVTCGTDRIV KIWDMTPVVG CSLATGFSPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDFY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 46 nTPM
placenta: 26 nTPM
lymph node: 22 nTPM
endometrium: 21 nTPM
thyroid gland: 21 nTPM
ovary: 20 nTPM

Single-cell type

choroid plexus epithelial cells: 74 nCPM
podocytes: 73 nCPM
microglia: 66 nCPM
oligodendrocytes: 63 nCPM
oligodendrocyte progenitor cells: 62 nCPM
proximal tubule cells: 54 nCPM

Immune cell

intermediate monocyte: 29 nTPM
non-classical monocyte: 26 nTPM
NK-cell: 24 nTPM
classical monocyte: 22 nTPM
total PBMC: 18 nTPM
MAIT T-cell: 17 nTPM

Brain region

pons: 24 nTPM
choroid plexus: 24 nTPM
thalamus: 23 nTPM
hypothalamus: 23 nTPM
white matter: 23 nTPM
midbrain: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 1.43
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDFY1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDFY1 as an antibody target. Whether an autoantibody or antibody against WDFY1 could matter depends on whether native WDFY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDFY1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDFY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...