Seroatlas · Human Serome Atlas

PWP1

Periodic tryptophan protein 1 homolog

Also known as: IEF-SSP-9502, PWP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13610
Gene
PWP1
Ensembl
ENSG00000136045
Chromosome
12
Canonical length
501 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli rim,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>Q13610|PWP1
     1  MNRSRQVTCV AWVRCGVAKE TPDKVELSKE EVKRLIAEAK EKLQEEGGGS DEEETGSPSE
    61  DGMQSARTQA RPREPLEDGD PEDDRTLDDD ELAEYDLDKY DEEGDPDAET LGESLLGLTV
   121  YGSNDQDPYV TLKDTEQYER EDFLIKPSDN LIVCGRAEQD QCNLEVHVYN QEEDSFYVHH
   181  DILLSAYPLS VEWLNFDPSP DDSTGNYIAV GNMTPVIEVW DLDIVDSLEP VFTLGSKLSK
   241  KKKKKGKKSS SAEGHTDAVL DLSWNKLIRN VLASASADNT VILWDMSLGK PAASLAVHTD
   301  KVQTLQFHPF EAQTLISGSY DKSVALYDCR SPDESHRMWR FSGQIERVTW NHFSPCHFLA
   361  STDDGFVYNL DARSDKPIFT LNAHNDEISG LDLSSQIKGC LVTASADKYV KIWDILGDRP
   421  SLVHSRDMKM GVLFCSSCCP DLPFIYAFGG QKEGLRVWDI STVSSVNEAF GRRERLVLGS
   481  ARNSSISGPF GSRSSDTPME S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PWP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 54 nTPM
  • tonsil: 35 nTPM
  • breast: 32 nTPM
  • ovary: 32 nTPM
  • blood vessel: 31 nTPM
  • parathyroid gland: 31 nTPM

Single-cell type

  • oocytes: 143 nCPM
  • late primary spermatocytes: 116 nCPM
  • esophageal basal cells: 107 nCPM
  • b-cells: 98 nCPM
  • gastric progenitor cells: 97 nCPM
  • differentiating spermatogonia: 94 nCPM

Immune cell

  • memory B-cell: 69 nTPM
  • naive B-cell: 64 nTPM
  • T-reg: 49 nTPM
  • naive CD8 T-cell: 48 nTPM
  • plasmacytoid DC: 47 nTPM
  • NK-cell: 44 nTPM

Brain region

  • choroid plexus: 48 nTPM
  • pons: 28 nTPM
  • hypothalamus: 25 nTPM
  • cerebral cortex: 25 nTPM
  • basal ganglia: 25 nTPM
  • cerebellum: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
1.28
DepMap mean gene effect
-0.73
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PWP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PWP1 as an antibody target. Whether an autoantibody or antibody against PWP1 could matter depends on whether native PWP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PWP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PWP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PWP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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