Seroatlas · Human Serome Atlas

SKIC8

Superkiller complex protein 8

Also known as: REC14, SKI8, SKI8_HUMAN, WDR61

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZS3
Gene
SKIC8
Ensembl
ENSG00000140395
Chromosome
15
Canonical length
305 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q9GZS3|SKIC8
     1  MTNQYGILFK QEQAHDDAIW SVAWGTNKKE NSETVVTGSL DDLVKVWKWR DERLDLQWSL
    61  EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQIK SIDAGPVDAW TLAFSPDSQY
   121  LATGTHVGKV NIFGVESGKK EYSLDTRGKF ILSIAYSPDG KYLASGAIDG IINIFDIATG
   181  KLLHTLEGHA MPIRSLTFSP DSQLLVTASD DGYIKIYDVQ HANLAGTLSG HASWVLNVAF
   241  CPDDTHFVSS SSDKSVKVWD VGTRTCVHTF FDHQDQVWGV KYNGNGSKIV SVGDDQEIHI
   301  YDCPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SKIC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.21
Highest tissue expression
110 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 110 nTPM
  • choroid plexus: 63 nTPM
  • bone marrow: 58 nTPM
  • kidney: 57 nTPM
  • breast: 56 nTPM
  • adrenal gland: 53 nTPM

Single-cell type

  • epididymal principal cells: 227 nCPM
  • late primary spermatocytes: 225 nCPM
  • esophageal suprabasal cells: 175 nCPM
  • breast lactating cells: 161 nCPM
  • epididymal efferent duct ciliated cells: 157 nCPM
  • epididymal efferent duct absorptive cells: 144 nCPM

Immune cell

  • myeloid DC: 134 nTPM
  • intermediate monocyte: 100 nTPM
  • classical monocyte: 91 nTPM
  • total PBMC: 89 nTPM
  • non-classical monocyte: 86 nTPM
  • T-reg: 73 nTPM

Brain region

  • cerebral cortex: 105 nTPM
  • white matter: 102 nTPM
  • cerebellum: 78 nTPM
  • midbrain: 61 nTPM
  • hippocampal formation: 59 nTPM
  • hypothalamus: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
DepMap mean gene effect
-0.81
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SKIC8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SKIC8 as an antibody target. Whether an autoantibody or antibody against SKIC8 could matter depends on whether native SKIC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SKIC8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SKIC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SKIC8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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