Seroatlas · Human Serome Atlas

STRN3

Striatin-3

Also known as: PPP2R6B, S/G2NA, SG2NA, STRN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13033
Gene: STRN3
Ensembl: ENSG00000196792
Chromosome: 14
Canonical length: 797 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments,Primary cilium,Cytosol

OverviewNCBI Gene

Enables armadillo repeat domain binding activity; enzyme binding activity; and protein-macromolecule adaptor activity. Involved in negative regulation of hippo signaling; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; nucleoplasm; and plasma membrane. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

797 residues, UniProt reviewed canonical sequence.

>Q13033|STRN3
     1  MDELAGGGGG GPGMAAPPRQ QQGPGGNLGL SPGGNGAAGG GGPPASEGAG PAAGPELSRP
    61  QQYTIPGILH YIQHEWARFE MERAHWEVER AELQARIAFL QGERKGQENL KKDLVRRIKM
   121  LEYALKQERA KYHKLKYGTE LNQGDLKMPT FESEETKDTE APTAPQNSQL TWKQGRQLLR
   181  QYLQEVGYTD TILDVRSQRV RSLLGLSNSE PNGSVETKNL EQILNGGESP KQKGQEIKRS
   241  SGDVLETFNF LENADDSDED EENDMIEGIP EGKDKHRMNK HKIGNEGLAA DLTDDPDTEE
   301  ALKEFDFLVT AEDGEGAGEA RSSGDGTEWD KDDLSPTAEV WDVDQGLISK LKEQYKKERK
   361  GKKGVKRANR TKLYDMIADL GDDELPHIPS GIINQSRSAS TRMTDHEGAR AEEAEPITFP
   421  SGGGKSFIMG SDDVLLSVLG LGDLADLTVT NDADYSYDLP ANKDAFRKTW NPKYTLRSHF
   481  DGVRALAFHP VEPVLVTASE DHTLKLWNLQ KTVPAKKSAS LDVEPIYTFR AHIGPVLSLA
   541  ISSNGEQCFS GGIDATIQWW NMPSPSVDPY DTYEPNVLAG TLVGHTDAVW GLAYSGIKNQ
   601  LLSCSADGTV RLWNPQEKLP CICTYNGDKK HGIPTSVDFI GCDPAHMVTS FNTGSAVIYD
   661  LETSQSLVIL SSQVDSGLQS NNHINRVVSH PTLPVTITAH EDRHIKFFDN KTGKMIHSMV
   721  AHLDAVTSLA VDPNGIYLMS GSHDCSIRLW NLDSKTCVQE ITAHRKKLDE SIYDVAFHSS
   781  KAYIASAGAD ALAKVFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STRN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 37 nTPM
tongue: 27 nTPM
liver: 20 nTPM
testis: 20 nTPM
adipose tissue: 18 nTPM
heart muscle: 17 nTPM

Single-cell type

myonuclei: 477 nCPM
neutrophil progenitors: 347 nCPM
neutrophils: 311 nCPM
somatotrophs: 309 nCPM
thyrotrophs: 308 nCPM
lactotrophs: 306 nCPM

Immune cell

plasmacytoid DC: 5.7 nTPM
naive CD8 T-cell: 4.9 nTPM
eosinophil: 4.7 nTPM
MAIT T-cell: 4.5 nTPM
intermediate monocyte: 4.3 nTPM
neutrophil: 4.3 nTPM

Brain region

hypothalamus: 56 nTPM
cerebellum: 53 nTPM
cerebral cortex: 45 nTPM
midbrain: 43 nTPM
white matter: 43 nTPM
choroid plexus: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.83
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STRN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STRN3 as an antibody target. Whether an autoantibody or antibody against STRN3 could matter depends on whether native STRN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STRN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STRN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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