Seroatlas · Human Serome Atlas

WDFY2

WD repeat and FYVE domain-containing protein 2

Also known as: WDFY2_HUMAN, ZFYVE22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96P53
Gene: WDFY2
Ensembl: ENSG00000139668
Chromosome: 13
Canonical length: 400 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>Q96P53|WDFY2
     1  MAAEIQPKPL TRKPILLQRM EGSQEVVNMA VIVPKEEGVI SVSEDRTVRV WLKRDSGQYW
    61  PSVYHAMPSP CSCMSFNPET RRLSIGLDNG TISEFILSED YNKMTPVKNY QAHQSRVTMI
   121  LFVLELEWVL STGQDKQFAW HCSESGQRLG GYRTSAVASG LQFDVETRHV FIGDHSGQVT
   181  ILKLEQENCT LVTTFRGHTG GVTALCWDPV QRVLFSGSSD HSVIMWDIGG RKGTAIELQG
   241  HNDRVQALSY AQHTRQLISC GGDGGIVVWN MDVERQETPE WLDSDSCQKC DQPFFWNFKQ
   301  MWDSKKIGLR QHHCRKCGKA VCGKCSSKRS SIPLMGFEFE VRVCDSCHEA ITDEERAPTA
   361  TFHDSKHNIV HVHFDATRGW LLTSGTDKVI KLWDMTPVVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDFY2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

skin: 17 nTPM
pancreas: 15 nTPM
bone marrow: 14 nTPM
parathyroid gland: 14 nTPM
adrenal gland: 10 nTPM
esophagus: 9 nTPM

Single-cell type

adrenal cortex cells: 710 nCPM
pancreatic acinar cells: 601 nCPM
distal convoluted tubule cells: 582 nCPM
monocyte progenitors: 517 nCPM
neutrophil progenitors: 498 nCPM
sertoli cells: 451 nCPM

Immune cell

myeloid DC: 13 nTPM
plasmacytoid DC: 12 nTPM
non-classical monocyte: 9.6 nTPM
intermediate monocyte: 8.6 nTPM
classical monocyte: 7.7 nTPM
basophil: 6.1 nTPM

Brain region

white matter: 32 nTPM
medulla oblongata: 28 nTPM
basal ganglia: 27 nTPM
hypothalamus: 24 nTPM
pons: 23 nTPM
thalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDFY2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDFY2 as an antibody target. Whether an autoantibody or antibody against WDFY2 could matter depends on whether native WDFY2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDFY2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDFY2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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