Seroatlas · Human Serome Atlas

THOC3

THO complex subunit 3

Also known as: MGC5469, TEX1, THOC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96J01
Gene
THOC3
Ensembl
ENSG00000051596
Chromosome
5
Canonical length
351 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>Q96J01|THOC3
     1  MAVPAAAMGP SALGQSGPGS MAPWCSVSSG PSRYVLGMQE LFRGHSKTRE FLAHSAKVHS
    61  VAWSCDGRRL ASGSFDKTAS VFLLEKDRLV KENNYRGHGD SVDQLCWHPS NPDLFVTASG
   121  DKTIRIWDVR TTKCIATVNT KGENINICWS PDGQTIAVGN KDDVVTFIDA KTHRSKAEEQ
   181  FKFEVNEISW NNDNNMFFLT NGNGCINILS YPELKPVQSI NAHPSNCICI KFDPMGKYFA
   241  TGSADALVSL WDVDELVCVR CFSRLDWPVR TLSFSHDGKM LASASEDHFI DIAEVETGDK
   301  LWEVQCESPT FTVAWHPKRP LLAFACDDKD GKYDSSREAG TVKLFGLPND S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THOC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
101 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 101 nTPM
  • esophagus: 80 nTPM
  • tonsil: 67 nTPM
  • bone marrow: 55 nTPM
  • choroid plexus: 50 nTPM
  • testis: 49 nTPM

Single-cell type

  • papillary tip epithelial cells: 112 nCPM
  • early spermatids: 106 nCPM
  • renal connecting tubule cells: 62 nCPM
  • late primary spermatocytes: 62 nCPM
  • late spermatids: 60 nCPM
  • esophageal apical cells: 43 nCPM

Immune cell

  • T-reg: 199 nTPM
  • naive CD4 T-cell: 152 nTPM
  • memory CD4 T-cell: 124 nTPM
  • naive B-cell: 111 nTPM
  • naive CD8 T-cell: 93 nTPM
  • total PBMC: 83 nTPM

Brain region

  • cerebral cortex: 128 nTPM
  • hippocampal formation: 122 nTPM
  • cerebellum: 65 nTPM
  • amygdala: 62 nTPM
  • choroid plexus: 45 nTPM
  • white matter: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0.03
gnomAD missense Z
2.05
DepMap mean gene effect
-1.3
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THOC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THOC3 as an antibody target. Whether an autoantibody or antibody against THOC3 could matter depends on whether native THOC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THOC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THOC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THOC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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