Seroatlas · Human Serome Atlas

ATG16L1

Autophagy-related protein 16-1

Also known as: A16L1_HUMAN, APG16L, ATG16A, ATG16L, FLJ10035, WDR30

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q676U5
Gene
ATG16L1
Ensembl
ENSG00000085978
Chromosome
2
Canonical length
607 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Cytosol,Equatorial segment,Mid piece,Principal piece
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

607 residues, UniProt reviewed canonical sequence.

>Q676U5|ATG16L1
     1  MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK
    61  HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK
   121  DREMQMNEAK IAECLQTISD LETECLDLRT KLCDLERANQ TLKDEYDALQ ITFTALEGKL
   181  RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI
   241  EVIVDETSDH TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT
   301  HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE VFGEKCEFKG
   361  SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL RHTLTGHSGK VLSAKFLLDN
   421  ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES
   481  IVREMELLGK ITALDLNPER TELLSCSRDD LLKVIDLRTN AIKQTFSAPG FKCGSDWTRV
   541  VFSPDGSYVA AGSAEGSLYI WSVLTGKVEK VLSKQHSSSI NAVAWSPSGS HVVSVDKGCK
   601  AVLWAQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATG16L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 24 nTPM
  • choroid plexus: 22 nTPM
  • skeletal muscle: 20 nTPM
  • skin: 17 nTPM
  • liver: 15 nTPM
  • cerebral cortex: 14 nTPM

Single-cell type

  • choroid plexus epithelial cells: 170 nCPM
  • brain inhibitory neurons: 31 nCPM
  • brain excitatory neurons: 28 nCPM
  • oligodendrocytes: 25 nCPM
  • microglia: 22 nCPM
  • podocytes: 21 nCPM

Immune cell

  • gdT-cell: 4.8 nTPM
  • non-classical monocyte: 4.7 nTPM
  • memory CD8 T-cell: 4.4 nTPM
  • NK-cell: 4.2 nTPM
  • T-reg: 3.8 nTPM
  • MAIT T-cell: 3.7 nTPM

Brain region

  • choroid plexus: 20 nTPM
  • cerebral cortex: 11 nTPM
  • cerebellum: 9.8 nTPM
  • white matter: 9.1 nTPM
  • basal ganglia: 8.8 nTPM
  • hippocampal formation: 8.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ATG16L1.

Disease | AllUniProt

Conditions ATG16L1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.96
gnomAD missense Z
2.63
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATG16L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATG16L1 as an antibody target. Whether an autoantibody or antibody against ATG16L1 could matter depends on whether native ATG16L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATG16L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATG16L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATG16L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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