WDR86
WD repeat-containing protein 86
Also known as: WDR86_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86TI4
- Gene
- WDR86
- Ensembl
- ENSG00000187260
- Chromosome
- 7
- Canonical length
- 376 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for WDR86 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
376 residues, UniProt reviewed canonical sequence.
>Q86TI4|WDR86
1 MGGGGSALRV CADHRGGINW LSLSPDGQRL LTGSEDGTAR LWSTADGQCC ALLQGHESYV
61 TFCQLEDEAA FTCSADCTIR RWDVLTGQCL QVYRGHTSIV NRILVANNQL FSSSYDRTAR
121 VWSVDKGQMS REFRGHRNCV LTLAYSAPWD LPSTPCAEEA AAGGLLVTGS TDGTAKVWQV
181 ASGCCHQTLR GHTGAVLCLV LDTPGHTAFT GSTDATIRAW DILSGEQLRV FREHRGSVIC
241 LELVNRLVYS GSADRTVKCW LADTGECVRT FTAHRRNVSA LKYHAGTLFT GSGDACARAF
301 DAQSGELRRV FRGHTFIINC IQVHGQVLYT ASHDGALRLW DVRGLRGAPR PPPPMRSLSR
361 LFSNKVGCAA APLQPALocalizationUniProt · AlphaFold · HPA
Whether an antibody against WDR86 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.26
- Highest tissue expression
- 28 nTPM
Expression across tissuesHPA
Tissue
- thyroid gland: 28 nTPM
- cervix: 19 nTPM
- spleen: 17 nTPM
- fallopian tube: 13 nTPM
- colon: 10 nTPM
- adipose tissue: 10 nTPM
Single-cell type
- ependymal cells: 71 nCPM
- pituicytes/fscs: 57 nCPM
- decidual stromal cells: 54 nCPM
- fallopian tube ciliated cells: 50 nCPM
- endometrial stromal cells: 43 nCPM
- epididymal efferent duct ciliated cells: 43 nCPM
Immune cell
- memory CD4 T-cell: 0.2 nTPM
- MAIT T-cell: 0.1 nTPM
- memory CD8 T-cell: 0.1 nTPM
- NK-cell: 0.1 nTPM
- non-classical monocyte: 0.1 nTPM
- basophil: 0 nTPM
Brain region
- amygdala: 17 nTPM
- choroid plexus: 17 nTPM
- cerebral cortex: 14 nTPM
- hippocampal formation: 13 nTPM
- midbrain: 10 nTPM
- basal ganglia: 8.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.51
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.53
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads WDR86 as an antibody target. Whether an autoantibody or antibody against WDR86 could matter depends on whether native WDR86 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
WDR86 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label WDR86 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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