Seroatlas · Human Serome Atlas

FBXW11

F-box/WD repeat-containing protein 11

Also known as: BTRC2, BTRCP2, Fbw11, Fbw1b, FBW1B_HUMAN, FBXW1B, Hos, KIAA0696

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKB1
Gene
FBXW11
Ensembl
ENSG00000072803
Chromosome
5
Canonical length
542 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>Q9UKB1|FBXW11
     1  MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQI SNGTSSVIVS
    61  RKRPSEGNYQ KEKDLCIKYF DQWSESDQVE FVEHLISRMC HYQHGHINSY LKPMLQRDFI
   121  TALPEQGLDH IAENILSYLD ARSLCAAELV CKEWQRVISE GMLWKKLIER MVRTDPLWKG
   181  LSERRGWDQY LFKNRPTDGP PNSFYRSLYP KIIQDIETIE SNWRCGRHNL QRIQCRSENS
   241  KGVYCLQYDD EKIISGLRDN SIKIWDKTSL ECLKVLTGHT GSVLCLQYDE RVIVTGSSDS
   301  TVRVWDVNTG EVLNTLIHHN EAVLHLRFSN GLMVTCSKDR SIAVWDMASA TDITLRRVLV
   361  GHRAAVNVVD FDDKYIVSAS GDRTIKVWST STCEFVRTLN GHKRGIACLQ YRDRLVVSGS
   421  SDNTIRLWDI ECGACLRVLE GHEELVRCIR FDNKRIVSGA YDGKIKVWDL QAALDPRAPA
   481  STLCLRTLVE HSGRVFRLQF DEFQIISSSH DDTILIWDFL NVPPSAQNET RSPSRTYTYI
   541  SR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXW11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 37 nTPM
  • retina: 35 nTPM
  • heart muscle: 34 nTPM
  • spinal cord: 33 nTPM
  • tongue: 33 nTPM
  • skeletal muscle: 32 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 340 nCPM
  • esophageal apical cells: 320 nCPM
  • alveolar cells type 2: 281 nCPM
  • urothelial cells: 276 nCPM
  • endometrial glandular cells: 258 nCPM
  • pdcs: 245 nCPM

Immune cell

  • basophil: 26 nTPM
  • NK-cell: 14 nTPM
  • plasmacytoid DC: 8.6 nTPM
  • memory B-cell: 8.5 nTPM
  • naive B-cell: 8.4 nTPM
  • classical monocyte: 7.3 nTPM

Brain region

  • white matter: 86 nTPM
  • hippocampal formation: 81 nTPM
  • hypothalamus: 79 nTPM
  • basal ganglia: 79 nTPM
  • thalamus: 78 nTPM
  • cerebral cortex: 76 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FBXW11.

Disease | AllUniProt

Conditions FBXW11 is implicated in, by any mechanism.

  • Neurodevelopmental, jaw, eye, and digital syndrome (NEDJED) MIM:618914

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 137 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental, jaw, eye, and digital syndrome

Disease | ImmuneIEDB

Conditions an epitope on FBXW11 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.98
gnomAD missense Z
3.96
DepMap mean gene effect
-0.44
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXW11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXW11 as an antibody target. Whether an autoantibody or antibody against FBXW11 could matter depends on whether native FBXW11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXW11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXW11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBXW11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...