Seroatlas · Human Serome Atlas

RBBP7

Histone-binding protein RBBP7

Also known as: RbAp46, RBBP7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16576
Gene
RBBP7
Ensembl
ENSG00000102054
Chromosome
X
Canonical length
425 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q16576|RBBP7
     1  MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP EVTKPEGKDY
    61  ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSD KGEFGGFGSV TGKIECEIKI
   121  NHEGEVNRAR YMPQNPHIIA TKTPSSDVLV FDYTKHPAKP DPSGECNPDL RLRGHQKEGY
   181  GLSWNSNLSG HLLSASDDHT VCLWDINAGP KEGKIVDAKA IFTGHSAVVE DVAWHLLHES
   241  LFGSVADDQK LMIWDTRSNT TSKPSHLVDA HTAEVNCLSF NPYSEFILAT GSADKTVALW
   301  DLRNLKLKLH TFESHKDEIF QVHWSPHNET ILASSGTDRR LNVWDLSKIG EEQSAEDAED
   361  GPPELLFIHG GHTAKISDFS WNPNEPWVIC SVSEDNIMQI WQMAENIYND EESDVTTSEL
   421  EGQGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RBBP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
278 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 278 nTPM
  • adrenal gland: 265 nTPM
  • parathyroid gland: 182 nTPM
  • seminal vesicle: 157 nTPM
  • skeletal muscle: 127 nTPM
  • cervix: 125 nTPM

Single-cell type

  • syncytiotrophoblasts: 621 nCPM
  • cytotrophoblasts: 530 nCPM
  • epididymal principal cells: 458 nCPM
  • migrating cytotrophoblasts: 398 nCPM
  • oocytes: 327 nCPM
  • adrenal cortex cells: 247 nCPM

Immune cell

  • non-classical monocyte: 112 nTPM
  • memory B-cell: 92 nTPM
  • memory CD8 T-cell: 89 nTPM
  • NK-cell: 89 nTPM
  • gdT-cell: 85 nTPM
  • naive CD8 T-cell: 83 nTPM

Brain region

  • choroid plexus: 64 nTPM
  • basal ganglia: 54 nTPM
  • white matter: 49 nTPM
  • cerebral cortex: 49 nTPM
  • hypothalamus: 45 nTPM
  • spinal cord: 42 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RBBP7.

Disease | AllUniProt

Conditions RBBP7 is implicated in, by any mechanism.

  • Spermatogenic failure, X-linked, 9 (SPGFX9) MIM:301137

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 144 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure, X-linked, 9

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.98
gnomAD missense Z
2.79
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RBBP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RBBP7 as an antibody target. Whether an autoantibody or antibody against RBBP7 could matter depends on whether native RBBP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RBBP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RBBP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RBBP7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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