Seroatlas · Human Serome Atlas

WDR83

WD repeat domain-containing protein 83

Also known as: MORG1, WDR83_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRX9
Gene
WDR83
Ensembl
ENSG00000123154
Chromosome
19
Canonical length
315 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Centriolar satellite,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q9BRX9|WDR83
     1  MAFPEPKPRP PELPQKRLKT LDCGQGAVRA VRFNVDGNYC LTCGSDKTLK LWNPLRGTLL
    61  RTYSGHGYEV LDAAGSFDNS SLCSGGGDKA VVLWDVASGQ VVRKFRGHAG KVNTVQFNEE
   121  ATVILSGSID SSIRCWDCRS RRPEPVQTLD EARDGVSSVK VSDHEILAGS VDGRVRRYDL
   181  RMGQLFSDYV GSPITCTCFS RDGQCTLVSS LDSTLRLLDK DTGELLGEYK GHKNQEYKLD
   241  CCLSERDTHV VSCSEDGKVF FWDLVEGALA LALPVGSGVV QSLAYHPTEP CLLTAMGGSV
   301  QCWREEAYEA EDGAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR83 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
9.8 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 9.8 nTPM
  • testis: 9.5 nTPM
  • cerebellum: 8.7 nTPM
  • midbrain: 8.1 nTPM
  • cerebral cortex: 7.9 nTPM
  • salivary gland: 7.7 nTPM

Single-cell type

  • late spermatids: 113 nCPM
  • epicardial cells: 89 nCPM
  • cardiomyocytes: 86 nCPM
  • megakaryocytes: 37 nCPM
  • late primary spermatocytes: 30 nCPM
  • fallopian tube ciliated cells: 30 nCPM

Immune cell

  • plasmacytoid DC: 24 nTPM
  • NK-cell: 22 nTPM
  • myeloid DC: 14 nTPM
  • classical monocyte: 13 nTPM
  • naive CD8 T-cell: 13 nTPM
  • intermediate monocyte: 12 nTPM

Brain region

  • white matter: 6.6 nTPM
  • cerebellum: 6.4 nTPM
  • basal ganglia: 6.3 nTPM
  • thalamus: 6.2 nTPM
  • hypothalamus: 6.1 nTPM
  • midbrain: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
0.1
DepMap mean gene effect
-0.42
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR83 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR83 as an antibody target. Whether an autoantibody or antibody against WDR83 could matter depends on whether native WDR83 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR83 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR83 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR83. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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