Seroatlas · Human Serome Atlas

WDR31

WD repeat-containing protein 31

Also known as: FLJ35921, WDR31_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NA23
Gene
WDR31
Ensembl
ENSG00000148225
Chromosome
9
Canonical length
367 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>Q8NA23|WDR31
     1  MLLLRCQLKQ APPQKVSFRF CVVMGKQQSK LKHSTYKYGR PDEIIEERIQ TKAFQEYSPA
    61  HMDTVSVVAA LNSDLCVSGG KDKTVVAYNW KTGNVVKRFK GHEHEITKVA CIPKSSQFFS
   121  ASRDRMVMMW DLHGSSQPRQ QLCGHAMVVT GLAVSPDSSQ LCTGSRDNTL LLWDVVTGQS
   181  VERASVSRNV VTHLCWVPRE PYILQTSEDK TLRLWDSRGL QVAHMFPAKQ HIQTYCEVSV
   241  DGHKCISCSN GFGGEGCEAT LWDLRQTRNR ICEYKGHFQT VASCVFLPRA LALMPLIATS
   301  SHDCKVKIWN QDTGACLFTL SLDGSGPLTS LAVGDAISLL CASFNRGIHL LRMDHSQGLE
   361  LQEVAAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • retina: 17 nTPM
  • parathyroid gland: 10 nTPM
  • heart muscle: 5.4 nTPM
  • testis: 4.5 nTPM
  • fallopian tube: 3.6 nTPM
  • salivary gland: 3.5 nTPM

Single-cell type

  • rod photoreceptor cells: 119 nCPM
  • cone photoreceptor cells: 77 nCPM
  • respiratory ciliated cells: 68 nCPM
  • early primary spermatocytes: 67 nCPM
  • ependymal cells: 43 nCPM
  • adrenal medulla cells: 43 nCPM

Immune cell

  • basophil: 1.5 nTPM
  • neutrophil: 0.8 nTPM
  • NK-cell: 0.4 nTPM
  • eosinophil: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • naive CD4 T-cell: 0.3 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • thalamus: 11 nTPM
  • midbrain: 11 nTPM
  • hypothalamus: 11 nTPM
  • basal ganglia: 11 nTPM
  • amygdala: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
0.66
DepMap mean gene effect
0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR31 as an antibody target. Whether an autoantibody or antibody against WDR31 could matter depends on whether native WDR31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR31. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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