Seroatlas · Human Serome Atlas

NLE1

Notchless protein homolog 1

Also known as: FLJ10458, NLE, NLE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NVX2
Gene
NLE1
Ensembl
ENSG00000073536
Chromosome
17
Canonical length
485 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to be involved in regulation of Notch signaling pathway. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and positive regulation of canonical Wnt signaling pathway. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q9NVX2|NLE1
     1  MAAAVPDEAV ARDVQRLLVQ FQDEGGQLLG SPFDVPVDIT PDRLQLVCNA LLAQEDPLPL
    61  AFFVHDAEIV SSLGKTLESQ AVETEKVLDI IYQPQAIFRV RAVTRCTSSL EGHSEAVISV
   121  AFSPTGKYLA SGSGDTTVRF WDLSTETPHF TCKGHRHWVL SISWSPDGRK LASGCKNGQI
   181  LLWDPSTGKQ VGRTLAGHSK WITGLSWEPL HANPECRYVA SSSKDGSVRI WDTTAGRCER
   241  ILTGHTQSVT CLRWGGDGLL YSASQDRTIK VWRAHDGVLC RTLQGHGHWV NTMALSTDYA
   301  LRTGAFEPAE ASVNPQDLQG SLQELKERAL SRYNLVRGQG PERLVSGSDD FTLFLWSPAE
   361  DKKPLTRMTG HQALINQVLF SPDSRIVASA SFDKSIKLWD GRTGKYLASL RGHVAAVYQI
   421  AWSADSRLLV SGSSDSTLKV WDVKAQKLAM DLPGHADEVY AVDWSPDGQR VASGGKDKCL
   481  RIWRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 23 nTPM
  • ovary: 11 nTPM
  • breast: 8.2 nTPM
  • esophagus: 7.9 nTPM
  • cerebral cortex: 7.3 nTPM
  • skeletal muscle: 7.2 nTPM

Single-cell type

  • pancreatic acinar cells: 27 nCPM
  • migrating cytotrophoblasts: 24 nCPM
  • esophageal basal cells: 24 nCPM
  • oocytes: 23 nCPM
  • extravillous trophoblasts: 22 nCPM
  • gastric chief cells: 21 nCPM

Immune cell

  • MAIT T-cell: 6.2 nTPM
  • naive CD4 T-cell: 5.2 nTPM
  • naive B-cell: 4.6 nTPM
  • memory CD8 T-cell: 4.2 nTPM
  • gdT-cell: 4 nTPM
  • memory CD4 T-cell: 3.8 nTPM

Brain region

  • cerebellum: 12 nTPM
  • cerebral cortex: 12 nTPM
  • basal ganglia: 11 nTPM
  • hypothalamus: 11 nTPM
  • medulla oblongata: 11 nTPM
  • white matter: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
0.56
DepMap mean gene effect
-0.94
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NLE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NLE1 as an antibody target. Whether an autoantibody or antibody against NLE1 could matter depends on whether native NLE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NLE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NLE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NLE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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