Seroatlas · Human Serome Atlas

STRN

Striatin

Also known as: PPP2R6A, STRN_HUMAN, STRN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43815
Gene: STRN
Ensembl: ENSG00000115808
Chromosome: 2
Canonical length: 780 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables armadillo repeat domain binding activity; nuclear estrogen receptor binding activity; and protein phosphatase 2A binding activity. Involved in Wnt signaling pathway and negative regulation of cell population proliferation. Located in bicellular tight junction. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

780 residues, UniProt reviewed canonical sequence.

>O43815|STRN
     1  MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP GILHFLQHEW
    61  ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR RIKMLEYALK QERAKYHKLK
   121  YGTELNQGDM KPPSYDSDEG NETEVQPQQN SQLMWKQGRQ LLRQYLQEVG YTDTILDVKS
   181  KRVRALLGFS SDVTDREDDK NQDSVVNGTE AEVKETAMIA KSELTDSASV LDNFKFLESA
   241  AADFSDEDED DDVDGREKSV IDTSTIVRKK ALPDSGEDRD TKEALKEFDF LVTSEEGDNE
   301  SRSAGDGTDW EKEDQCLMPE AWNVDQGVIT KLKEQYKKER KGKKGVKRPN RSKLQDMLAN
   361  LRDVDELPSL QPSVGSPSRP SSSRLPEHEI NRADEVEALT FPPSSGKSFI MGADEALESE
   421  LGLGELAGLT VANEADSLTY DIANNKDALR KTWNPKFTLR SHFDGIRALA FHPIEPVLIT
   481  ASEDHTLKMW NLQKTAPAKK STSLDVEPIY TFRAHKGPVL CVVMSSNGEQ CYSGGTDGLI
   541  QGWNTTNPNI DPYDSYDPSV LRGPLLGHTD AVWGLAYSAA HQRLLSCSAD GTLRLWNTTE
   601  VAPALSVFND TKELGIPASV DLVSSDPSHM VASFSKGYTS IFNMETQQRI LTLESNVDTT
   661  ANSSCQINRV ISHPTLPISI TAHEDRHIKF YDNNTGKLIH SMVAHLEAVT SLAVDPNGLY
   721  LMSGSHDCSI RLWNLESKTC IQEFTAHRKK FEESIHDVAF HPSKCYIASA GADALAKVFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STRN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

esophagus: 20 nTPM
heart muscle: 20 nTPM
bone marrow: 14 nTPM
spinal cord: 14 nTPM
thymus: 12 nTPM
tonsil: 12 nTPM

Single-cell type

esophageal apical cells: 435 nCPM
oligodendrocytes: 320 nCPM
urothelial cells: 286 nCPM
ocular epithelial cells: 228 nCPM
neutrophils: 212 nCPM
suprabasal keratinocytes: 211 nCPM

Immune cell

basophil: 1.3 nTPM
neutrophil: 1 nTPM
gdT-cell: 0.5 nTPM
eosinophil: 0.4 nTPM
intermediate monocyte: 0.4 nTPM
memory B-cell: 0.4 nTPM

Brain region

white matter: 72 nTPM
basal ganglia: 57 nTPM
thalamus: 52 nTPM
medulla oblongata: 51 nTPM
cerebellum: 48 nTPM
midbrain: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.66
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STRN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STRN as an antibody target. Whether an autoantibody or antibody against STRN could matter depends on whether native STRN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STRN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STRN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...