Seroatlas · Human Serome Atlas

PAK1IP1

p21-activated protein kinase-interacting protein 1

Also known as: bA421M1.5, FLJ20624, hPIP1, MAK11, PIP1, PK1IP_HUMAN, WDR84

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NWT1
Gene
PAK1IP1
Ensembl
ENSG00000111845
Chromosome
6
Canonical length
392 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

Predicted to enable protein kinase inhibitor activity. Involved in regulation of signal transduction by p53 class mediator and ribosomal large subunit biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q9NWT1|PAK1IP1
     1  MELVAGCYEQ VLFGFAVHPE PEACGDHEQW TLVADFTHHA HTASLSAVAV NSRFVVTGSK
    61  DETIHIYDMK KKIEHGALVH HSGTITCLKF YGNRHLISGA EDGLICIWDA KKWECLKSIK
   121  AHKGQVTFLS IHPSGKLALS VGTDKTLRTW NLVEGRSAFI KNIKQNAHIV EWSPRGEQYV
   181  VIIQNKIDIY QLDTASISGT ITNEKRISSV KFLSESVLAV AGDEEVIRFF DCDSLVCLCE
   241  FKAHENRVKD MFSFEIPEHH VIVSASSDGF IKMWKLKQDK KVPPSLLCEI NTNARLTCLG
   301  VWLDKVADMK ESLPPAAEPS PVSKEQSKIG KKEPGDTVHK EEKRSKPNTK KRGLTGDSKK
   361  ATKESGLIST KKRKMVEMLE KKRKKKKIKT MQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAK1IP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 39 nTPM
  • esophagus: 19 nTPM
  • skeletal muscle: 17 nTPM
  • adipose tissue: 15 nTPM
  • liver: 13 nTPM
  • endometrium: 12 nTPM

Single-cell type

  • erythrocyte progenitors: 50 nCPM
  • basal keratinocytes: 35 nCPM
  • esophageal basal cells: 34 nCPM
  • differentiating spermatogonia: 33 nCPM
  • suprabasal keratinocytes: 32 nCPM
  • gastric progenitor cells: 31 nCPM

Immune cell

  • plasmacytoid DC: 14 nTPM
  • naive CD8 T-cell: 14 nTPM
  • intermediate monocyte: 12 nTPM
  • myeloid DC: 12 nTPM
  • naive CD4 T-cell: 11 nTPM
  • non-classical monocyte: 10 nTPM

Brain region

  • white matter: 8.2 nTPM
  • hypothalamus: 6.8 nTPM
  • cerebral cortex: 6.7 nTPM
  • midbrain: 6.7 nTPM
  • medulla oblongata: 6.4 nTPM
  • pons: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.36
gnomAD missense Z
0.83
DepMap mean gene effect
-1.29
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAK1IP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAK1IP1 as an antibody target. Whether an autoantibody or antibody against PAK1IP1 could matter depends on whether native PAK1IP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAK1IP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAK1IP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PAK1IP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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