Seroatlas · Human Serome Atlas

WDR17

WD repeat-containing protein 17

Also known as: WDR17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZU2
Gene
WDR17
Ensembl
ENSG00000150627
Chromosome
4
Canonical length
1322 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

1322 residues, UniProt reviewed canonical sequence.

>Q8IZU2|WDR17
     1  MAWMTYISNW FEQDDWYEGL QRANMSQVRQ VGLLAAGCQP WNKDVCAASG DRFAYCATLA
    61  IYIYQLDHRY NEFKLHAIMS EHKKTITAIS WCPHNPDLFA SGSTDNLVII WNVAEQKVIA
   121  KLDSTKGIPA SLSWCWNAED VVAFVSHRGP LFIWTISGPD SGVIVHKDAH SFLSDICMFR
   181  WHTHQKGKVV FGHIDGSLSI FHPGNKNQKH VLRPESLEGT DEEDPVTALE WDPLSTDYLL
   241  VVNLHYGIRL VDSESLSCIT TFNLPSAAAS VQCLAWVPSA PGMFITGDSQ VGVLRIWNVS
   301  RTTPIDNLKL KKTGFHCLHV LNSPPRKKFS VQSPTKNHYT SSTSEAVPPP TLTQNQAFSL
   361  PPGHAVCCFL DGGVGLYDMG AKKWDFLRDL GHVETIFDCK FKPDDPNLLA TASFDGTIKV
   421  WDINTLTAVY TSPGNEGVIY SLSWAPGGLN CIAGGTSRNG AFIWNVQKGK IIQRFNEHGT
   481  NGIFCIAWSH KDSKRIATCS SDGFCIIRTI DGKVLHKYKH PAAVFGCDWS QNNKDMIATG
   541  CEDTNVRVYY VATSSDQPLK VFSGHTAKVF HVKWSPLREG ILCSGSDDGT VRIWDYTQDA
   601  CINILNGHTA PVRGLMWNTE IPYLLISGSW DYTIKVWDTR EGTCVDTVYD HGADVYGLTC
   661  HPSRPFTMAS CSRDSTVRLW SLTALVTPVQ INILADRSWE EIIGNTDYAI EPGTPPLLCG
   721  KVSRDIRQEI EKLTANSQVK KLRWFSECLS PPGGSDNLWN LVAVIKGQDD SLLPQNYCKG
   781  IMHLKHLIKF RTSEAQELTT VKMSKFGGGI GVPAKEERLK EAAEIHLRLG QIQRYCELMV
   841  ELGEWDKALS IAPGVSVKYW KKLMQRRADQ LIQEDKDDVI PYCIAIGDVK KLVHFFMSRG
   901  QLKEALLVAQ AACEGNMQPL HVSVPKGASY SDDIYKEDFN ELLHKVSKEL AEWYFQDGRA
   961  VLAACCHLAI DNIELAMAYL IRGNELELAV CVGTVLGESA APATHYALEL LARKCMMISV
  1021  CFPCVGYSVP FCYVNRNLAA DLLLMIPDNE LHLIKLCAFY PGCTEEINDL HDKCKLPTVE
  1081  ECMQLAETAR ADDNIFETVK YYLLSQEPEK ALPIGISFVK EYISSSDWTL DTIYPVLDLL
  1141  SYIRTEKLLL HTCTEARNEL LILCGYIGAL LAIRRQYQSI VPALYEYTSQ LLKRREVSVP
  1201  LKIEYLSEEL DAWRACTQST NRSLEDSPYT PPSDSQRMIY ATLLKRLKEE SLKGIIGPDY
  1261  VTGSNLPSHS DIHISCLTGL KIQGPVFFLE DGKSAISLND ALMWAKVNPF SPLGTGIRLN
  1321  PF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • retina: 26 nTPM
  • cerebral cortex: 11 nTPM
  • pituitary gland: 9 nTPM
  • cerebellum: 8.3 nTPM
  • basal ganglia: 6.7 nTPM
  • parathyroid gland: 6.5 nTPM

Single-cell type

  • brain inhibitory neurons: 273 nCPM
  • thyrotrophs: 247 nCPM
  • rod photoreceptor cells: 237 nCPM
  • cone photoreceptor cells: 236 nCPM
  • bergmann glia: 232 nCPM
  • astrocytes: 229 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • intermediate monocyte: 0.2 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 43 nTPM
  • basal ganglia: 42 nTPM
  • hippocampal formation: 35 nTPM
  • amygdala: 34 nTPM
  • white matter: 32 nTPM
  • cerebellum: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR17.

Disease | ImmuneIEDB

Conditions an epitope on WDR17 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
0.49
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR17 as an antibody target. Whether an autoantibody or antibody against WDR17 could matter depends on whether native WDR17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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