Seroatlas · Human Serome Atlas

STRN4

Striatin-4

Also known as: PPP2R6C, STRN4_HUMAN, ZIN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRL3
Gene
STRN4
Ensembl
ENSG00000090372
Chromosome
19
Canonical length
753 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables armadillo repeat domain binding activity; protein phosphatase 2A binding activity; and protein-macromolecule adaptor activity. Involved in negative regulation of hippo signaling. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

753 residues, UniProt reviewed canonical sequence.

>Q9NRL3|STRN4
     1  MMEERAAAAV AAAASSCRPL GSGAGPGPTG AAPVSAPAPG PGPAGKGGGG GGSPGPTAGP
    61  EPLSLPGILH FIQHEWARFE AEKARWEAER AELQAQVAFL QGERKGQENL KTDLVRRIKM
   121  LEYALKQERA KYHKLKFGTD LNQGEKKADV SEQVSNGPVE SVTLENSPLV WKEGRQLLRQ
   181  YLEEVGYTDT ILDMRSKRVR SLLGRSLELN GAVEPSEGAP RAPPGPAGLS GGESLLVKQI
   241  EEQIKRNAAG KDGKERLGGS VLGQIPFLQN CEDEDSDEDD ELDSVQHKKQ RVKLPSKALV
   301  PEMEDEDEED DSEDAINEFD FLGSGEDGEG APDPRRCTVD GSPHELESRR VKLQGILADL
   361  RDVDGLPPKV TGPPPGTPQP RPHEDVFIMD TIGGGEVSLG DLADLTVTND NDLSCDLSDS
   421  KDAFKKTWNP KFTLRSHYDG IRSLAFHHSQ SALLTASEDG TLKLWNLQKA VTAKKNAALD
   481  VEPIHAFRAH RGPVLAVAMG SNSEYCYSGG ADACIHSWKI PDLSMDPYDG YDPSVLSHVL
   541  EGHGDAVWGL AFSPTSQRLA SCSADGTVRI WDPSSSSPAC LCTFPTASEH GVPTSVAFTS
   601  TEPAHIVASF RSGDTVLYDM EVGSALLTLE SRGSSGPTQI NQVVSHPNQP LTITAHDDRG
   661  IRFLDNRTGK PVHSMVAHLD AVTCLAVDPN GAFLMSGSHD CSLRLWSLDN KTCVQEITAH
   721  RKKHEEAIHA VACHPSKALI ASAGADALAK VFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STRN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • testis: 82 nTPM
  • esophagus: 47 nTPM
  • hippocampal formation: 43 nTPM
  • blood vessel: 42 nTPM
  • spleen: 41 nTPM
  • skin: 41 nTPM

Single-cell type

  • platelets: 176 nCPM
  • megakaryocytes: 155 nCPM
  • undifferentiated spermatogonia: 60 nCPM
  • neutrophils: 46 nCPM
  • esophageal apical cells: 41 nCPM
  • differentiating spermatogonia: 40 nCPM

Immune cell

  • neutrophil: 9.3 nTPM
  • intermediate monocyte: 9.1 nTPM
  • classical monocyte: 5.9 nTPM
  • total PBMC: 5.8 nTPM
  • non-classical monocyte: 5.7 nTPM
  • basophil: 4 nTPM

Brain region

  • hippocampal formation: 62 nTPM
  • cerebral cortex: 57 nTPM
  • amygdala: 48 nTPM
  • basal ganglia: 47 nTPM
  • hypothalamus: 46 nTPM
  • white matter: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
2.29
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STRN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STRN4 as an antibody target. Whether an autoantibody or antibody against STRN4 could matter depends on whether native STRN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STRN4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STRN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STRN4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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