Seroatlas · Human Serome Atlas

RAE1

mRNA export factor RAE1

Also known as: Gle2, Mnrp41, RAE1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78406
Gene: RAE1
Ensembl: ENSG00000101146
Chromosome: 20
Canonical length: 368 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>P78406|RAE1
     1  MSLFGTTSGF GTSGTSMFGS ATTDNHNPMK DIEVTSSPDD SIGCLSFSPP TLPGNFLIAG
    61  SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLSSNQA
   121  IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD KTLKFWDTRS SNPMMVLQLP ERCYCADVIY
   181  PMAVVATAER GLIVYQLENQ PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV
   241  AIHYINPPNP AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW
   301  DKDARTKLKT SEQLDQPISA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK NYIFLRNAAE
   361  ELKPRNKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

testis: 96 nTPM
bone marrow: 48 nTPM
thymus: 27 nTPM
tonsil: 25 nTPM
cerebellum: 24 nTPM
skin: 23 nTPM

Single-cell type

oocytes: 387 nCPM
late primary spermatocytes: 385 nCPM
early spermatids: 118 nCPM
neutrophil progenitors: 114 nCPM
early primary spermatocytes: 99 nCPM
differentiating spermatogonia: 94 nCPM

Immune cell

eosinophil: 77 nTPM
classical monocyte: 42 nTPM
total PBMC: 40 nTPM
non-classical monocyte: 38 nTPM
intermediate monocyte: 37 nTPM
neutrophil: 36 nTPM

Brain region

hypothalamus: 28 nTPM
white matter: 24 nTPM
basal ganglia: 23 nTPM
cerebral cortex: 23 nTPM
cerebellum: 22 nTPM
hippocampal formation: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 2.68
DepMap mean gene effect: -1.48
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RAE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAE1 as an antibody target. Whether an autoantibody or antibody against RAE1 could matter depends on whether native RAE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RAE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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