Seroatlas · Human Serome Atlas

WDR5B

WD repeat-containing protein 5B

Also known as: FLJ11287, WDR5B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VZ2
Gene: WDR5B
Ensembl: ENSG00000196981
Chromosome: 3
Canonical length: 330 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This intronless gene encodes a protein containing several WD40 repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, including a trp-asp at the C-terminal end. The encoded protein may mediate protein-protein interactions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>Q86VZ2|WDR5B
     1  MATKESRDAK AQLALSSSAN QSKEVPENPN YALKCTLVGH TEAVSSVKFS PNGEWLASSS
    61  ADRLIIIWGA YDGKYEKTLY GHNLEISDVA WSSDSSRLVS ASDDKTLKLW DVRSGKCLKT
   121  LKGHSNYVFC CNFNPPSNLI ISGSFDETVK IWEVKTGKCL KTLSAHSDPV SAVHFNCSGS
   181  LIVSGSYDGL CRIWDAASGQ CLKTLVDDDN PPVSFVKFSP NGKYILTATL DNTLKLWDYS
   241  RGRCLKTYTG HKNEKYCIFA NFSVTGGKWI VSGSEDNLVY IWNLQTKEIV QKLQGHTDVV
   301  ISAACHPTEN LIASAALEND KTIKLWMSNH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 9 nTPM

Expression across tissuesHPA

Tissue

epididymis: 9 nTPM
fallopian tube: 6.6 nTPM
retina: 6.6 nTPM
thyroid gland: 6.3 nTPM
breast: 5.8 nTPM
pancreas: 5.3 nTPM

Single-cell type

late primary spermatocytes: 21 nCPM
respiratory ciliated cells: 15 nCPM
epicardial cells: 14 nCPM
epididymal principal cells: 14 nCPM
medullary thymic epithelial cells: 12 nCPM
fallopian tube ciliated cells: 11 nCPM

Immune cell

non-classical monocyte: 4.3 nTPM
basophil: 3 nTPM
naive CD4 T-cell: 2.8 nTPM
T-reg: 2.3 nTPM
intermediate monocyte: 2.1 nTPM
naive CD8 T-cell: 2.1 nTPM

Brain region

white matter: 7 nTPM
cerebellum: 6 nTPM
choroid plexus: 5.9 nTPM
medulla oblongata: 5.5 nTPM
basal ganglia: 5.4 nTPM
midbrain: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

histone binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR5B as an antibody target. Whether an autoantibody or antibody against WDR5B could matter depends on whether native WDR5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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