Seroatlas · Human Serome Atlas

MLST8

Target of rapamycin complex subunit LST8

Also known as: GbetaL, GBL, Lst8, LST8_HUMAN, Pop3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BVC4
Gene
MLST8
Ensembl
ENSG00000167965
Chromosome
16
Canonical length
326 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cell Junctions

OverviewNCBI Gene

Enables protein serine/threonine kinase activator activity and protein-macromolecule adaptor activity. Involved in TOR signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex; TORC2 complex; and serine/threonine protein kinase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>Q9BVC4|MLST8
     1  MNTSPGTVGS DPVILATAGY DHTVRFWQAH SGICTRTVQH QDSQVNALEV TPDRSMIAAA
    61  GYQHIRMYDL NSNNPNPIIS YDGVNKNIAS VGFHEDGRWM YTGGEDCTAR IWDLRSRNLQ
   121  CQRIFQVNAP INCVCLHPNQ AELIVGDQSG AIHIWDLKTD HNEQLIPEPE VSITSAHIDP
   181  DASYMAAVNS TGNCYVWNLT GGIGDEVTQL IPKTKIPAHT RYALQCRFSP DSTLLATCSA
   241  DQTCKIWRTS NFSLMTELSI KSGNPGESSR GWMWGCAFSG DSQYIVTASS DNLARLWCVE
   301  TGEIKREYGG HQKAVVCLAF NDSVLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MLST8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 49 nTPM
  • hippocampal formation: 42 nTPM
  • amygdala: 42 nTPM
  • cerebellum: 39 nTPM
  • basal ganglia: 38 nTPM
  • pancreas: 37 nTPM

Single-cell type

  • late spermatids: 181 nCPM
  • late primary spermatocytes: 79 nCPM
  • esophageal basal cells: 76 nCPM
  • migrating cytotrophoblasts: 76 nCPM
  • cytotrophoblasts: 74 nCPM
  • esophageal suprabasal cells: 62 nCPM

Immune cell

  • non-classical monocyte: 30 nTPM
  • intermediate monocyte: 30 nTPM
  • classical monocyte: 25 nTPM
  • myeloid DC: 25 nTPM
  • total PBMC: 21 nTPM
  • memory CD8 T-cell: 15 nTPM

Brain region

  • cerebral cortex: 47 nTPM
  • white matter: 38 nTPM
  • thalamus: 37 nTPM
  • pons: 35 nTPM
  • hippocampal formation: 35 nTPM
  • amygdala: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.01
gnomAD missense Z
1.38
DepMap mean gene effect
-0.47
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MLST8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MLST8 as an antibody target. Whether an autoantibody or antibody against MLST8 could matter depends on whether native MLST8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MLST8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MLST8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MLST8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...