Seroatlas · Human Serome Atlas

TAF5L

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

Also known as: PAF65B, TAF5L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75529
Gene: TAF5L
Ensembl: ENSG00000135801
Chromosome: 1
Canonical length: 589 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytoplasmic bodies

OverviewNCBI Gene

The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

589 residues, UniProt reviewed canonical sequence.

>O75529|TAF5L
     1  MKRVRTEQIQ MAVSCYLKRR QYVDSDGPLK QGLRLSQTAE EMAANLTVQS ESGCANIVSA
    61  APCQAEPQQY EVQFGRLRNF LTDSDSQHSH EVMPLLYPLF VYLHLNLVQN SPKSTVESFY
   121  SRFHGMFLQN ASQKDVIEQL QTTQTIQDIL SNFKLRAFLD NKYVVRLQED SYNYLIRYLQ
   181  SDNNTALCKV LTLHIHLDVQ PAKRTDYQLY ASGSSSRSEN NGLEPPDMPS PILQNEAALE
   241  VLQESIKRVK DGPPSLTTIC FYAFYNTEQL LNTAEISPDS KLLAAGFDNS CIKLWSLRSK
   301  KLKSEPHQVD VSRIHLACDI LEEEDDEDDN AGTEMKILRG HCGPVYSTRF LADSSGLLSC
   361  SEDMSIRYWD LGSFTNTVLY QGHAYPVWDL DISPYSLYFA SGSHDRTARL WSFDRTYPLR
   421  IYAGHLADVD CVKFHPNSNY LATGSTDKTV RLWSAQQGNS VRLFTGHRGP VLSLAFSPNG
   481  KYLASAGEDQ RLKLWDLASG TLYKELRGHT DNITSLTFSP DSGLIASASM DNSVRVWDIR
   541  NTYCSAPADG SSSELVGVYT GQMSNVLSVQ FMACNLLLVT GITQENQEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 21 nTPM
bone marrow: 21 nTPM
skeletal muscle: 19 nTPM
adipose tissue: 15 nTPM
liver: 14 nTPM
placenta: 13 nTPM

Single-cell type

extravillous trophoblasts: 73 nCPM
paneth cells: 50 nCPM
medullary thymic epithelial cells: 38 nCPM
neutrophil progenitors: 37 nCPM
corticotrophs: 34 nCPM
vascular smooth muscle cells: 31 nCPM

Immune cell

MAIT T-cell: 0.5 nTPM
NK-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM
memory CD4 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM

Brain region

white matter: 19 nTPM
cerebellum: 18 nTPM
thalamus: 18 nTPM
basal ganglia: 17 nTPM
medulla oblongata: 17 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 2.37
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription coactivator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF5L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF5L as an antibody target. Whether an autoantibody or antibody against TAF5L could matter depends on whether native TAF5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF5L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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