Seroatlas · Human Serome Atlas

FBXW9

F-box/WD repeat-containing protein 9

Also known as: Fbw9, FBXW9_HUMAN, MEC-15, MGC10870

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5XUX1
Gene
FBXW9
Ensembl
ENSG00000132004
Chromosome
19
Canonical length
458 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Members of the F-box protein family, such as FBXW9, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>Q5XUX1|FBXW9
     1  MELPLGRCDD SRTWDDDSDP ESETDPDAQA KAYVARVLSP PKSGLAFSRP SQLSTPAASP
    61  SASEPRAASR VSAVSEPGLL SLPPELLLEI CSYLDARLVL HVLSRVCHAL RDLVSDHVTW
   121  RLRALRRVRA PYPVVEEKNF DWPAACIALE QHLSRWAEDG RWVEYFCLAE GHVASVDSVL
   181  LLQGGSLCLS GSRDRNVNLW DLRQLGTESN QVLIKTLGTK RNSTHEGWVW SLAAQDHRVC
   241  SGSWDSTVKL WDMAADGQQF GEIKASSAVL CLSYLPDILV TGTYDKKVTI YDPRAGPALL
   301  KHQQLHSRPV LTLLADDRHI ISGSEDHTLV VVDRRANSVL QRLQLDSYLL CMSYQEPQLW
   361  AGDNQGLLHV FANRNGCFQL IRSFDVGHSF PITGIQYSVG ALYTTSTDKT IRVHVPTDPP
   421  RTICTRRHDN GLNRVCAEGN LVVAGSGDLS LEVWRLQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXW9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 19 nTPM
  • testis: 14 nTPM
  • fallopian tube: 12 nTPM
  • esophagus: 10 nTPM
  • kidney: 9.2 nTPM
  • skin: 9.1 nTPM

Single-cell type

  • megakaryocytes: 124 nCPM
  • fallopian tube ciliated cells: 89 nCPM
  • respiratory ciliated cells: 77 nCPM
  • endometrial ciliated cells: 76 nCPM
  • epididymal efferent duct ciliated cells: 60 nCPM
  • late primary spermatocytes: 40 nCPM

Immune cell

  • myeloid DC: 11 nTPM
  • classical monocyte: 7.5 nTPM
  • intermediate monocyte: 7.1 nTPM
  • T-reg: 5.7 nTPM
  • total PBMC: 5 nTPM
  • non-classical monocyte: 4.9 nTPM

Brain region

  • choroid plexus: 18 nTPM
  • midbrain: 12 nTPM
  • hippocampal formation: 8.3 nTPM
  • cerebral cortex: 8 nTPM
  • basal ganglia: 7.6 nTPM
  • hypothalamus: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
0.62
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXW9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXW9 as an antibody target. Whether an autoantibody or antibody against FBXW9 could matter depends on whether native FBXW9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXW9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXW9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBXW9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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