Seroatlas · Human Serome Atlas

ATG16L2

Protein Atg16l2

Also known as: A16L2_HUMAN, ATG16B, FLJ00012, WDR80

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NAA4
Gene
ATG16L2
Ensembl
ENSG00000168010
Chromosome
11
Canonical length
619 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm
Quaternary structure
Homooligomer

OverviewNCBI Gene

Predicted to be involved in autophagosome assembly. Predicted to act upstream of or within negative stranded viral RNA replication. Located in nucleoplasm. Part of Atg12-Atg5-Atg16 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>Q8NAA4|ATG16L2
     1  MAGPGVPGAP AARWKRHIVR QLRLRDRTQK ALFLELVPAY NHLLEKAELL DKFSKKLQPE
    61  PNSVTPTTHQ GPWEESELDS DQVPSLVALR VKWQEEEEGL RLVCGEMAYQ VVEKGAALGT
   121  LESELQQRQS RLAALEARVA QLREARAQQA QQVEEWRAQN AVQRAAYEAL RAHVGLREAA
   181  LRRLQEEARD LLERLVQRKA RAAAERNLRN ERRERAKQAR VSQELKKAAK RTVSISEGPD
   241  TLGDGMRERR ETLALAPEPE PLEKEACEKW KRPFRSASAT SLTLSHCVDV VKGLLDFKKR
   301  RGHSIGGAPE QRYQIIPVCV AARLPTRAQD VLDAHLSEVN AVRFGPNSSL LATGGADRLI
   361  HLWNVVGSRL EANQTLEGAG GSITSVDFDP SGYQVLAATY NQAAQLWKVG EAQSKETLSG
   421  HKDKVTAAKF KLTRHQAVTG SRDRTVKEWD LGRAYCSRTI NVLSYCNDVV CGDHIIISGH
   481  NDQKIRFWDS RGPHCTQVIP VQGRVTSLSL SHDQLHLLSC SRDNTLKVID LRVSNIRQVF
   541  RADGFKCGSD WTKAVFSPDR SYALAGSCDG ALYIWDVDTG KLESRLQGPH CAAVNAVAWC
   601  YSGSHMVSVD QGRKVVLWQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATG16L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
129 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 129 nTPM
  • spleen: 129 nTPM
  • skin: 69 nTPM
  • lung: 41 nTPM
  • small intestine: 33 nTPM
  • lymph node: 32 nTPM

Single-cell type

  • neutrophils: 604 nCPM
  • neutrophil progenitors: 150 nCPM
  • monocytes: 104 nCPM
  • microglia: 99 nCPM
  • cdc: 95 nCPM
  • hematopoietic stem cells: 94 nCPM

Immune cell

  • neutrophil: 60 nTPM
  • eosinophil: 46 nTPM
  • classical monocyte: 16 nTPM
  • non-classical monocyte: 12 nTPM
  • myeloid DC: 11 nTPM
  • intermediate monocyte: 9.3 nTPM

Brain region

  • thalamus: 27 nTPM
  • white matter: 26 nTPM
  • cerebral cortex: 25 nTPM
  • cerebellum: 25 nTPM
  • medulla oblongata: 22 nTPM
  • amygdala: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.08
gnomAD pLI
0
gnomAD missense Z
1.06
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATG16L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATG16L2 as an antibody target. Whether an autoantibody or antibody against ATG16L2 could matter depends on whether native ATG16L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATG16L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATG16L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATG16L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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