Seroatlas · Human Serome Atlas

DAW1

Dynein assembly factor with WD repeat domains 1

Also known as: DAW1_HUMAN, DNAAF18, FLJ25955, ODA16, WDR69

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N136
Gene
DAW1
Ensembl
ENSG00000123977
Chromosome
2
Canonical length
415 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in protein polyubiquitination. Predicted to act upstream of with a positive effect on outer dynein arm assembly. Predicted to act upstream of or within with a positive effect on intraciliary transport. Predicted to act upstream of or within several processes, including cerebrospinal fluid circulation; determination of left/right symmetry; and heart development. Predicted to be located in ciliary basal body. Predicted to be part of SCF ubiquitin ligase complex. Implicated in primary ciliary dyskinesia. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

415 residues, UniProt reviewed canonical sequence.

>Q8N136|DAW1
     1  MKLKSLLLRY YPPGIMLEYE KHGELKTKSI DLLDLGPSTD VSALVEEIQK AEPLLTASRT
    61  EQVKLLIQRL QEKLGQNSNH TFYLFKVLKA HILPLTNVAL NKSGSCFITG SYDRTCKLWD
   121  TASGEELNTL EGHRNVVYAI AFNNPYGDKI ATGSFDKTCK LWSVETGKCY HTFRGHTAEI
   181  VCLSFNPQST LVATGSMDTT AKLWDIQNGE EVYTLRGHSA EIISLSFNTS GDRIITGSFD
   241  HTVVVWDADT GRKVNILIGH CAEISSASFN WDCSLILTGS MDKTCKLWDA TNGKCVATLT
   301  GHDDEILDSC FDYTGKLIAT ASADGTARIF SAATRKCIAK LEGHEGEISK ISFNPQGNHL
   361  LTGSSDKTAR IWDAQTGQCL QVLEGHTDEI FSCAFNYKGN IVITGSKDNT CRIWR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DAW1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 55 nTPM
  • testis: 48 nTPM
  • fallopian tube: 31 nTPM
  • skeletal muscle: 8.3 nTPM
  • basal ganglia: 6.7 nTPM
  • hippocampal formation: 4.1 nTPM

Single-cell type

  • late primary spermatocytes: 388 nCPM
  • late spermatids: 332 nCPM
  • ependymal cells: 309 nCPM
  • respiratory ciliated cells: 225 nCPM
  • fallopian tube ciliated cells: 184 nCPM
  • choroid plexus epithelial cells: 146 nCPM

Immune cell

  • basophil: 0.9 nTPM
  • neutrophil: 0.3 nTPM
  • MAIT T-cell: 0.2 nTPM
  • naive B-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM

Brain region

  • choroid plexus: 51 nTPM
  • midbrain: 18 nTPM
  • medulla oblongata: 14 nTPM
  • spinal cord: 13 nTPM
  • hypothalamus: 11 nTPM
  • white matter: 10 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DAW1.

Disease | AllUniProt

Conditions DAW1 is implicated in, by any mechanism.

  • Ciliary dyskinesia, primary, 52 (CILD52) MIM:620570

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 75 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
0.16
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DAW1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DAW1 as an antibody target. Whether an autoantibody or antibody against DAW1 could matter depends on whether native DAW1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DAW1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DAW1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DAW1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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