Seroatlas · Human Serome Atlas

FBXW10B

F-box and WD repeat domain containing protein 10B

Also known as: CDRT1, CDRT1_HUMAN, FBXW10P1, HREP, SM25H2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95170
Gene: FBXW10B
Ensembl: ENSG00000241322
Chromosome: 17
Canonical length: 752 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

752 residues, UniProt reviewed canonical sequence.

>O95170|FBXW10B
     1  MENLESRLKN APYFRCEKGT DSIPLCRKCE TRVLAWKIFS TKEWFCRIND ISQRRFLVGI
    61  LKQLNSLYLL HYFQNILQTT QGKDFIYNRS RIDLSKKEGK VVKSSLNQML DKTVEQKMKE
   121  ILYWFANSTQ WTKANYTLLL LQMCNPKLLL TAANVIRVLF LREENNISGL NQDITDVCFS
   181  PEKDHSSKSA TSQVYWTAKT QHTSLPLSKA PENEHFLGAA SNPEEPWRNS LRCISEMNRL
   241  FSGKADITKP GYDPCNLLVD LDDIRDLSSG FSKYRDFIRY LPIHLSKYIL RMLDRHTLNK
   301  CASVSQHWAA MAQQVKMDLS AHGFIQNQIT FLQGSYTRGI DPNYANKVSI PVPKMVDDGK
   361  SMRVKHPKWK LRTKNEYNLW TAYQNEETQQ VLMEERNVFC GTYNVRILSD TWDQNRVIHY
   421  SGGDLIAVSS NRKIHLLDII QVKAIPVEFR GHAGSVRALF LCEEENFLLS GSYDLSIRYW
   481  DLKSGVCTRI FGGHQGTITC MDLCKNRLVS GGRDCQVKVW DVDTGKCLKT FRHKDPILAT
   541  RINDTYIVSS CERGLVKVWH IAMAQLVKTL SGHEGAVKCL FFDQWHLLSG STDGLVMAWS
   601  MVGKYERCLM AFKHPKEVLD VSLLFLRVIS ACADGKIRIY NFFNGNCMKV IKANGRGDPV
   661  LSFFIQGNRI SVCHISTFAK RINVGWNGIE PSATAQGGNA SLTECAHVRL HIAGHLPASR
   721  LPVAAVQPMT GGMAPTTAPT HVLAMLILFS GV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXW10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
esophagus: 7.8 nTPM
vagina: 3.7 nTPM
skin: 3.3 nTPM
cervix: 2.9 nTPM
adrenal gland: 2.3 nTPM

Single-cell type

early spermatids: 20 nCPM
late primary spermatocytes: 19 nCPM
late spermatids: 10 nCPM
ependymal cells: 5.2 nCPM
foveolar cells: 3.1 nCPM
brain inhibitory neurons: 2.2 nCPM

Immune cell

T-reg: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 3.9 nTPM
cerebellum: 3.8 nTPM
thalamus: 3.8 nTPM
medulla oblongata: 3.7 nTPM
midbrain: 3.7 nTPM
amygdala: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXW10B as an antibody target. Whether an autoantibody or antibody against FBXW10B could matter depends on whether native FBXW10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXW10B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXW10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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