Seroatlas · Human Serome Atlas

COPB2

Coatomer subunit beta'

Also known as: beta'-COP, betaprime-COP, COPB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35606
Gene
COPB2
Ensembl
ENSG00000184432
Chromosome
3
Canonical length
906 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Golgi apparatus

OverviewNCBI Gene

The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

906 residues, UniProt reviewed canonical sequence.

>P35606|COPB2
     1  MPLRLDIKRK LTARSDRVKS VDLHPTEPWM LASLYNGSVC VWNHETQTLV KTFEVCDLPV
    61  RAAKFVARKN WVVTGADDMQ IRVFNYNTLE RVHMFEAHSD YIRCIAVHPT QPFILTSSDD
   121  MLIKLWDWDK KWSCSQVFEG HTHYVMQIVI NPKDNNQFAS ASLDRTIKVW QLGSSSPNFT
   181  LEGHEKGVNC IDYYSGGDKP YLISGADDRL VKIWDYQNKT CVQTLEGHAQ NVSCASFHPE
   241  LPIIITGSED GTVRIWHSST YRLESTLNYG MERVWCVASL RGSNNVALGY DEGSIIVKLG
   301  REEPAMSMDA NGKIIWAKHS EVQQANLKAM GDAEIKDGER LPLAVKDMGS CEIYPQTIQH
   361  NPNGRFVVVC GDGEYIIYTA MALRNKSFGS AQEFAWAHDS SEYAIRESNS IVKIFKNFKE
   421  KKSFKPDFGA ESIYGGFLLG VRSVNGLAFY DWDNTELIRR IEIQPKHIFW SDSGELVCIA
   481  TEESFFILKY LSEKVLAAQE THEGVTEDGI EDAFEVLGEI QEIVKTGLWV GDCFIYTSSV
   541  NRLNYYVGGE IVTIAHLDRT MYLLGYIPKD NRLYLGDKEL NIISYSLLVS VLEYQTAVMR
   601  RDFSMADKVL PTIPKEQRTR VAHFLEKQGF KQQALTVSTD PEHRFELALQ LGELKIAYQL
   661  AVEAESEQKW KQLAELAISK CQFGLAQECL HHAQDYGGLL LLATASGNAN MVNKLAEGAE
   721  RDGKNNVAFM SYFLQGKVDA CLELLIRTGR LPEAAFLART YLPSQVSRVV KLWRENLSKV
   781  NQKAAESLAD PTEYENLFPG LKEAFVVEEW VKETHADLWP AKQYPLVTPN EERNVMEEGK
   841  DFQPSRSTAQ QELDGKPASP TPVIVASHTA NKEEKSLLEL EVDLDNLELE DIDTTDINLD
   901  EDILDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
80 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 80 nTPM
  • cervix: 72 nTPM
  • prostate: 68 nTPM
  • rectum: 67 nTPM
  • salivary gland: 67 nTPM
  • liver: 67 nTPM

Single-cell type

  • esophageal apical cells: 245 nCPM
  • breast lactating cells: 238 nCPM
  • syncytiotrophoblasts: 219 nCPM
  • epididymal principal cells: 209 nCPM
  • plasma cells: 197 nCPM
  • pancreatic acinar cells: 175 nCPM

Immune cell

  • basophil: 75 nTPM
  • myeloid DC: 58 nTPM
  • non-classical monocyte: 58 nTPM
  • intermediate monocyte: 57 nTPM
  • eosinophil: 52 nTPM
  • classical monocyte: 50 nTPM

Brain region

  • choroid plexus: 72 nTPM
  • white matter: 45 nTPM
  • hypothalamus: 42 nTPM
  • spinal cord: 39 nTPM
  • thalamus: 39 nTPM
  • medulla oblongata: 38 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COPB2.

Disease | AllUniProt

Conditions COPB2 is implicated in, by any mechanism.

  • Microcephaly 19, primary, autosomal recessive (MCPH19) MIM:617800
  • Osteoporosis, childhood- or juvenile-onset, with developmental delay (OPDD) MIM:619884

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 236 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Osteoporosis, childhood- or juvenile-onset, with developmental delay
  • Microcephaly 19, primary, autosomal recessive
  • Inborn genetic diseases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.09
gnomAD pLI
1
gnomAD missense Z
2.56
DepMap mean gene effect
-2.21
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPB2 as an antibody target. Whether an autoantibody or antibody against COPB2 could matter depends on whether native COPB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COPB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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