Seroatlas · Human Serome Atlas

WSB1

WD repeat and SOCS box-containing protein 1

Also known as: DKFZp564A122, DKFZp564B0482, SWIP1, WSB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6I7
Gene
WSB1
Ensembl
ENSG00000109046
Chromosome
17
Canonical length
421 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q9Y6I7|WSB1
     1  MASFPPRVNE KEIVRLRTIG ELLAPAAPFD KKCGRENWTV AFAPDGSYFA WSQGHRTVKL
    61  VPWSQCLQNF LLHGTKNVTN SSSLRLPRQN SDGGQKNKPR EHIIDCGDIV WSLAFGSSVP
   121  EKQSRCVNIE WHRFRFGQDQ LLLATGLNNG RIKIWDVYTG KLLLNLVDHT EVVRDLTFAP
   181  DGSLILVSAS RDKTLRVWDL KDDGNMMKVL RGHQNWVYSC AFSPDSSMLC SVGASKAVFL
   241  WNMDKYTMIR KLEGHHHDVV ACDFSPDGAL LATASYDTRV YIWDPHNGDI LMEFGHLFPP
   301  PTPIFAGGAN DRWVRSVSFS HDGLHVASLA DDKMVRFWRI DEDYPVQVAP LSNGLCCAFS
   361  TDGSVLAAGT HDGSVYFWAT PRQVPSLQHL CRMSIRRVMP TQEVQELPIP SKLLEFLSYR
   421  I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WSB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 71 nTPM
  • retina: 70 nTPM
  • spleen: 66 nTPM
  • blood vessel: 61 nTPM
  • lung: 55 nTPM
  • bone marrow: 46 nTPM

Single-cell type

  • neutrophils: 1,225 nCPM
  • syncytiotrophoblasts: 1,163 nCPM
  • renal connecting tubule cells: 1,066 nCPM
  • kupffer cells: 988 nCPM
  • alveolar cells type 2: 775 nCPM
  • sertoli cells: 765 nCPM

Immune cell

  • non-classical monocyte: 83 nTPM
  • basophil: 75 nTPM
  • eosinophil: 72 nTPM
  • intermediate monocyte: 70 nTPM
  • myeloid DC: 66 nTPM
  • classical monocyte: 41 nTPM

Brain region

  • white matter: 207 nTPM
  • medulla oblongata: 131 nTPM
  • pons: 125 nTPM
  • hypothalamus: 120 nTPM
  • basal ganglia: 120 nTPM
  • thalamus: 114 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.42
gnomAD missense Z
0.25
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WSB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WSB1 as an antibody target. Whether an autoantibody or antibody against WSB1 could matter depends on whether native WSB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WSB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WSB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WSB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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