Seroatlas · Human Serome Atlas

SEH1L

Nucleoporin SEH1

Also known as: SEC13L, Seh1, SEH1_HUMAN, SEH1A, SEH1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96EE3
Gene
SEH1L
Ensembl
ENSG00000085415
Chromosome
18
Canonical length
360 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q96EE3|SEH1L
     1  MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSESGDWHCT ASWKTHSGSV
    61  WRVTWAHPEF GQVLASCSFD RTAAVWEEIV GESNDKLRGQ SHWVKRTTLV DSRTSVTDVK
   121  FAPKHMGLML ATCSADGIVR IYEAPDVMNL SQWSLQHEIS CKLSCSCISW NPSSSRAHSP
   181  MIAVGSDDSS PNAMAKVQIF EYNENTRKYA KAETLMTVTD PVHDIAFAPN LGRSFHILAI
   241  ATKDVRIFTL KPVRKELTSS GGPTKFEIHI VAQFDNHNSQ VWRVSWNITG TVLASSGDDG
   301  CVRLWKANYM DNWKCTGILK GNGSPVNGSS QQGTSNPSLG STIPSLQNSL NGSSAGRKHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEH1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 35 nTPM
  • cerebral cortex: 28 nTPM
  • tongue: 25 nTPM
  • hippocampal formation: 23 nTPM
  • thymus: 22 nTPM
  • cerebellum: 21 nTPM

Single-cell type

  • epicardial cells: 84 nCPM
  • suprabasal keratinocytes: 79 nCPM
  • basal keratinocytes: 73 nCPM
  • megakaryocyte progenitors: 67 nCPM
  • megakaryocyte-erythroid progenitors: 66 nCPM
  • esophageal basal cells: 64 nCPM

Immune cell

  • myeloid DC: 38 nTPM
  • intermediate monocyte: 32 nTPM
  • non-classical monocyte: 27 nTPM
  • naive B-cell: 24 nTPM
  • memory B-cell: 24 nTPM
  • NK-cell: 24 nTPM

Brain region

  • cerebral cortex: 38 nTPM
  • hippocampal formation: 38 nTPM
  • hypothalamus: 35 nTPM
  • white matter: 33 nTPM
  • basal ganglia: 31 nTPM
  • cerebellum: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.15
gnomAD missense Z
1.74
DepMap mean gene effect
-1.25
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEH1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEH1L as an antibody target. Whether an autoantibody or antibody against SEH1L could matter depends on whether native SEH1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEH1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEH1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEH1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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