Seroatlas · Human Serome Atlas

PWP2

Periodic tryptophan protein 2 homolog

Also known as: EHOC-17, PWP2_HUMAN, PWP2H, UTP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15269
Gene: PWP2
Ensembl: ENSG00000241945
Chromosome: 21
Canonical length: 919 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

919 residues, UniProt reviewed canonical sequence.

>Q15269|PWP2
     1  MKFAYRFSNL LGTVYRRGNL NFTCDGNSVI SPVGNRVTVF DLKNNKSDTL PLATRYNVKC
    61  VGLSPDGRLA IIVDEGGDAL LVSLVCRSVL HHFHFKGSVH SVSFSPDGRK FVVTKGNIAQ
   121  MYHAPGKKRE FNAFVLDKTY FGPYDETTCI DWTDDSRCFV VGSKDMSTWV FGAERWDNLI
   181  YYALGGHKDA IVACFFESNS LDLYSLSQDG VLCMWQCDTP PEGLRLKPPA GWKADLLQRE
   241  EEEEEEEDQE GDRETTIRGK ATPAEEEKTG KVKYSRLAKY FFNKEGDFNN LTAAAFHKKS
   301  HLLVTGFASG IFHLHELPEF NLIHSLSISD QSIASVAINS SGDWIAFGCS GLGQLLVWEW
   361  QSESYVLKQQ GHFNSMVALA YSPDGQYIVT GGDDGKVKVW NTLSGFCFVT FTEHSSGVTG
   421  VTFTATGYVV VTSSMDGTVR AFDLHRYRNF RTFTSPRPTQ FSCVAVDASG EIVSAGAQDS
   481  FEIFVWSMQT GRLLDVLSGH EGPISGLCFN PMKSVLASAS WDKTVRLWDM FDSWRTKETL
   541  ALTSDALAVT FRPDGAELAV ATLNSQITFW DPENAVQTGS IEGRHDLKTG RKELDKITAK
   601  HAAKGKAFTA LCYSADGHSI LAGGMSKFVC IYHVREQILM KRFEISCNLS LDAMEEFLNR
   661  RKMTEFGNLA LIDQDAGQED GVAIPLPGVR KGDMSSRHFK PEIRVTSLRF SPTGRCWAAT
   721  TTEGLLIYSL DTRVLFDPFE LDTSVTPGRV REALRQQDFT RAILMALRLN ESKLVQEALE
   781  AVPRGEIEVV TSSLPELYVE KVLEFLASSF EVSRHLEFYL LWTHKLLMLH GQKLKSRAGT
   841  LLPVIQFLQK SIQRHLDDLS KLCSWNHYNM QYALAVSKQR GTKRSLDPLG SEEEAEASED
   901  DSLHLLGGGG RDSEEEMLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PWP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

lymph node: 16 nTPM
appendix: 13 nTPM
spleen: 13 nTPM
bone marrow: 13 nTPM
urinary bladder: 13 nTPM
adipose tissue: 13 nTPM

Single-cell type

kupffer cells: 9.2 nCPM
megakaryocyte progenitors: 5.5 nCPM
colonocytes: 4.9 nCPM
enteric stem cells: 4.9 nCPM
goblet cells: 4.1 nCPM
enteric transient amplifying cells: 3.1 nCPM

Immune cell

MAIT T-cell: 29 nTPM
gdT-cell: 25 nTPM
non-classical monocyte: 23 nTPM
naive CD8 T-cell: 21 nTPM
memory CD8 T-cell: 20 nTPM
memory B-cell: 17 nTPM

Brain region

white matter: 46 nTPM
pons: 30 nTPM
basal ganglia: 28 nTPM
cerebral cortex: 27 nTPM
medulla oblongata: 24 nTPM
cerebellum: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: -1.23
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PWP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UTP18

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PWP2 as an antibody target. Whether an autoantibody or antibody against PWP2 could matter depends on whether native PWP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PWP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PWP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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