Seroatlas · Human Serome Atlas

CFAP337

Cilia- and flagella-associated protein 337

Also known as: CF337_HUMAN, FLJ33620, WDR49

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IV35
Gene: CFAP337
Ensembl: ENSG00000174776
Chromosome: 3
Canonical length: 1049 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Primary cilium tip,Primary cilium transition zone,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family with nine WD repeats. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

1049 residues, UniProt reviewed canonical sequence.

>Q8IV35|CFAP337
     1  MSCQKAVLEL NIGSQLGPKS PERTEGVTAF EDYGTGLLEN QLSVGDFVKI QKAFESPQPR
    61  KIICMSREDF TQKMTEIVGW GTKEEYGELF DKVDVAQDGF INWDKLTSFI LLELYEQDER
   121  AKATVVPQWK DLEFLPVKHK DTIQKVIFLK NSSHYLTISK EGLLAIWGEH LKLQETFPIT
   181  SDATKLKHLW VTSLVSLENV NKIAVAFTSK EVCFYDLLSK EEFACQYKLQ GLKGTPICMD
   241  YWYDPLDANE SILSFGDITG KVQAIAFTAA LISLFERPAS ACEDGEATMT INWAELLSGC
   301  HKCCHILEHK LHQGDWVRQV TYNASLDAII SSTTSNTNSV VMAWREKSKK RLNMTSFNIA
   361  QGIHAFDYHS RLNLIATAGI NNKVCLWNPY VVSKPVGVLW GHSASVIAVQ FFVERKQLFS
   421  FSKDKVLRLW DIQHQLSIQR IACSFPKSQD FRCLFHFDEA HGRLFISFNN QLALLAMKSE
   481  ASKRVKSHEK AVTCVLYNSI LKQVISSDTG STVSFWMIDT GQKIKQFTGC HGNAEISTMA
   541  LDANETRLLT GSTDGTVKIW DFNGYCHHTL NVGQDGAVDI SQILILKKKI LVTGWERYDY
   601  ASWKTIGRAI TVFRPQNFNQ FFIQPEEWKG GIQHHDDILC AAFLPPQTLV TGSYDGEIVL
   661  WNNSTENAHH VLHPDYQRLL KSKLDTKPQK LLSAGRSQPS HPMADHSTTG VRNFEIDTEG
   721  KNAVMRLCFL KARKNTAVTG GANLVSCGGS GYVRFWDIYK KQLLAEFLAH SGVGSIIMST
   781  DKMNRYLTTG DLDGWLKIWN IEEYCLNSSK NKITKAPTLI RSFQPHEDRI SSLEMCEPGG
   841  QLLIISSSAD CSICVTGVCN APVWIFGQAK HWHIENCLFL PKRDTNLVES EIQKEISLFS
   901  KEESCLDPTE HSLLNKKNKD DSTYNVRPSE DINLDIKYKE RSTCMKETQK PYYGEVIKKS
   961  FSTFRSLNIG ALEELPEVNK PAFLLDPEKY FRKEPEEERP QILEAPSLFK TLKAVFDEKN
  1021  LFPKEILHHE RKAKQLCQEK SCEVKKNKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CFAP337 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 8.8 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 8.8 nTPM
fallopian tube: 8.5 nTPM
small intestine: 4.2 nTPM
duodenum: 1.9 nTPM
cerebral cortex: 1.8 nTPM
bone marrow: 1.7 nTPM

Single-cell type

ependymal cells: 1,534 nCPM
respiratory ciliated cells: 1,021 nCPM
choroid plexus epithelial cells: 747 nCPM
bergmann glia: 618 nCPM
endometrial ciliated cells: 464 nCPM
podocytes: 406 nCPM

Immune cell

plasmacytoid DC: 2.9 nTPM
classical monocyte: 2.7 nTPM
myeloid DC: 2.2 nTPM
total PBMC: 0.5 nTPM
intermediate monocyte: 0.3 nTPM
naive B-cell: 0.1 nTPM

Brain region

spinal cord: 66 nTPM
medulla oblongata: 64 nTPM
choroid plexus: 61 nTPM
midbrain: 57 nTPM
white matter: 49 nTPM
cerebellum: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

calcium ion binding

Cellular components

cilium

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CFAP337 as an antibody target. Whether an autoantibody or antibody against CFAP337 could matter depends on whether native CFAP337 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CFAP337 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CFAP337 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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