Seroatlas · Human Serome Atlas

GNB2

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Also known as: GBB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62879
Gene
GNB2
Ensembl
ENSG00000172354
Chromosome
7
Canonical length
340 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>P62879|GNB2
     1  MSELEQLRQE AEQLRNQIRD ARKACGDSTL TQITAGLDPV GRIQMRTRRT LRGHLAKIYA
    61  MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNI
   121  CSIYSLKTRE GNVRVSRELP GHTGYLSCCR FLDDNQIITS SGDTTCALWD IETGQQTVGF
   181  AGHSGDVMSL SLAPDGRTFV SGACDASIKL WDVRDSMCRQ TFIGHESDIN AVAFFPNGYA
   241  FTTGSDDATC RLFDLRADQE LLMYSHDNII CGITSVAFSR SGRLLLAGYD DFNCNIWDAM
   301  KGDRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GNB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
318 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 318 nTPM
  • skin: 285 nTPM
  • spleen: 218 nTPM
  • vagina: 210 nTPM
  • blood vessel: 208 nTPM
  • adrenal gland: 205 nTPM

Single-cell type

  • esophageal apical cells: 1,494 nCPM
  • esophageal suprabasal cells: 574 nCPM
  • neutrophils: 574 nCPM
  • extravillous trophoblasts: 393 nCPM
  • esophageal basal cells: 351 nCPM
  • syncytiotrophoblasts: 333 nCPM

Immune cell

  • neutrophil: 118 nTPM
  • eosinophil: 72 nTPM
  • intermediate monocyte: 43 nTPM
  • non-classical monocyte: 36 nTPM
  • classical monocyte: 29 nTPM
  • myeloid DC: 28 nTPM

Brain region

  • medulla oblongata: 178 nTPM
  • hypothalamus: 172 nTPM
  • basal ganglia: 168 nTPM
  • thalamus: 167 nTPM
  • midbrain: 158 nTPM
  • amygdala: 157 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GNB2.

Disease | AllUniProt

Conditions GNB2 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with hypotonia and dysmorphic facies (NEDHYDF) MIM:619503
  • Sick sinus syndrome 4 (SSS4) MIM:619464

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 109 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.99
gnomAD missense Z
3.21
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GNB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GNB2 as an antibody target. Whether an autoantibody or antibody against GNB2 could matter depends on whether native GNB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GNB2 is annotated at the cell surface, where native GNB2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GNB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GNB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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