Seroatlas · Human Serome Atlas

WDSUB1

WD repeat, SAM and U-box domain-containing protein 1

Also known as: FLJ36175, UBOX6, WDSAM1, WSDU1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9V3
Gene: WDSUB1
Ensembl: ENSG00000196151
Chromosome: 2
Canonical length: 476 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q8N9V3|WDSUB1
     1  MVKLIHTLAD HGDDVNCCAF SFSLLATCSL DKTIRLYSLR DFTELPHSPL KFHTYAVHCC
    61  CFSPSGHILA SCSTDGTTVL WNTENGQMLA VMEQPSGSPV RVCQFSPDST CLASGAADGT
   121  VVLWNAQSYK LYRCGSVKDG SLAACAFSPN GSFFVTGSSC GDLTVWDDKM RCLHSEKAHD
   181  LGITCCDFSS QPVSDGEQGL QFFRLASCGQ DCQVKIWIVS FTHILGFELK YKSTLSGHCA
   241  PVLACAFSHD GQMLVSGSVD KSVIVYDTNT ENILHTLTQH TRYVTTCAFA PNTLLLATGS
   301  MDKTVNIWQF DLETLCQARR TEHQLKQFTE DWSEEDVSTW LCAQDLKDLV GIFKMNNIDG
   361  KELLNLTKES LADDLKIESL GLRSKVLRKI EELRTKVKSL SSGIPDEFIC PITRELMKDP
   421  VIASDGYSYE KEAMENWISK KKRTSPMTNL VLPSAVLTPN RTLKMAINRW LETHQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDSUB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

kidney: 22 nTPM
epididymis: 17 nTPM
thyroid gland: 16 nTPM
parathyroid gland: 13 nTPM
ovary: 12 nTPM
choroid plexus: 12 nTPM

Single-cell type

cardiomyocytes: 212 nCPM
thyrotrophs: 156 nCPM
somatotrophs: 139 nCPM
podocytes: 123 nCPM
epicardial cells: 109 nCPM
adrenal cortex cells: 106 nCPM

Immune cell

NK-cell: 21 nTPM
gdT-cell: 14 nTPM
myeloid DC: 12 nTPM
memory B-cell: 12 nTPM
plasmacytoid DC: 12 nTPM
classical monocyte: 11 nTPM

Brain region

choroid plexus: 19 nTPM
white matter: 19 nTPM
cerebellum: 17 nTPM
basal ganglia: 16 nTPM
medulla oblongata: 15 nTPM
pons: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein ubiquitination

Molecular functions

ubiquitin-protein transferase activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDSUB1 as an antibody target. Whether an autoantibody or antibody against WDSUB1 could matter depends on whether native WDSUB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDSUB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDSUB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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