Seroatlas · Human Serome Atlas

PLRG1

Pleiotropic regulator 1

Also known as: Cwc1, PLRG1_HUMAN, PRL1, Prp46, PRPF46, TANGO4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43660
Gene: PLRG1
Ensembl: ENSG00000171566
Chromosome: 4
Canonical length: 514 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane,Nucleoli fibrillar center,Nuclear speckles
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>O43660|PLRG1
     1  MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT
    61  SKENLKEKGP QNATDSYVHK QYPANQGQEV EYFVAGTHPY PPGPGVALTA DTKIQRMPSE
   121  SAAQSLAVAL PLQTKADANR TAPSGSEYRH PGASDRPQPT AMNSIVMETG NTKNSALMAK
   181  KAPTMPKPQW HPPWKLYRVI SGHLGWVRCI AVEPGNQWFV TGSADRTIKI WDLASGKLKL
   241  SLTGHISTVR GVIVSTRSPY LFSCGEDKQV KCWDLEYNKV IRHYHGHLSA VYGLDLHPTI
   301  DVLVTCSRDS TARIWDVRTK ASVHTLSGHT NAVATVRCQA AEPQIITGSH DTTIRLWDLV
   361  AGKTRVTLTN HKKSVRAVVL HPRHYTFASG SPDNIKQWKF PDGSFIQNLS GHNAIINTLT
   421  VNSDGVLVSG ADNGTMHLWD WRTGYNFQRV HAAVQPGSLD SESGIFACAF DQSESRLLTA
   481  EADKTIKVYR EDDTATEETH PVSWKPEIIK RKRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

tonsil: 48 nTPM
smooth muscle: 42 nTPM
liver: 41 nTPM
parathyroid gland: 39 nTPM
thymus: 38 nTPM
tongue: 37 nTPM

Single-cell type

esophageal suprabasal cells: 66 nCPM
late primary spermatocytes: 61 nCPM
esophageal basal cells: 61 nCPM
cytotrophoblasts: 58 nCPM
decidual stromal cells: 56 nCPM
oocytes: 55 nCPM

Immune cell

NK-cell: 68 nTPM
non-classical monocyte: 64 nTPM
T-reg: 56 nTPM
basophil: 53 nTPM
MAIT T-cell: 50 nTPM
total PBMC: 49 nTPM

Brain region

white matter: 62 nTPM
spinal cord: 52 nTPM
hypothalamus: 50 nTPM
medulla oblongata: 45 nTPM
midbrain: 38 nTPM
basal ganglia: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 2.45
DepMap mean gene effect: -1.18
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLRG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLRG1 as an antibody target. Whether an autoantibody or antibody against PLRG1 could matter depends on whether native PLRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLRG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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