Seroatlas · Human Serome Atlas

WDR5

WD repeat-containing protein 5

Also known as: CFAP89, SWD3, WDR5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61964
Gene
WDR5
Ensembl
ENSG00000196363
Chromosome
9
Canonical length
334 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Principal piece

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>P61964|WDR5
     1  MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL
    61  ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK
   121  CLKTLKGHSN YVFCCNFNPQ SNLIVSGSFD ESVRIWDVKT GKCLKTLPAH SDPVSAVHFN
   181  RDGSLIVSSS YDGLCRIWDT ASGQCLKTLI DDDNPPVSFV KFSPNGKYIL AATLDNTLKL
   241  WDYSKGKCLK TYTGHKNEKY CIFANFSVTG GKWIVSGSED NLVYIWNLQT KEIVQKLQGH
   301  TDVVISTACH PTENIIASAA LENDKTIKLW KSDC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • testis: 37 nTPM
  • liver: 33 nTPM
  • skeletal muscle: 32 nTPM
  • cerebellum: 30 nTPM
  • pancreas: 26 nTPM
  • pituitary gland: 24 nTPM

Single-cell type

  • late primary spermatocytes: 211 nCPM
  • early spermatids: 146 nCPM
  • differentiating spermatogonia: 61 nCPM
  • cone photoreceptor cells: 56 nCPM
  • esophageal basal cells: 54 nCPM
  • extravillous trophoblasts: 54 nCPM

Immune cell

  • myeloid DC: 10 nTPM
  • classical monocyte: 9.3 nTPM
  • plasmacytoid DC: 8.3 nTPM
  • total PBMC: 7.1 nTPM
  • memory CD8 T-cell: 6.9 nTPM
  • naive CD4 T-cell: 6.8 nTPM

Brain region

  • cerebellum: 31 nTPM
  • hypothalamus: 28 nTPM
  • cerebral cortex: 27 nTPM
  • basal ganglia: 26 nTPM
  • white matter: 26 nTPM
  • choroid plexus: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR5.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 60 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • WDR5-related neurodevelopmental delay

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.12
gnomAD pLI
1
gnomAD missense Z
3.39
DepMap mean gene effect
-0.99
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR5 as an antibody target. Whether an autoantibody or antibody against WDR5 could matter depends on whether native WDR5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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