Seroatlas · Human Serome Atlas

GRWD1

Glutamate-rich WD repeat-containing protein 1

Also known as: GRWD, GRWD1_HUMAN, RRB1, WDR28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQ67
Gene: GRWD1
Ensembl: ENSG00000105447
Chromosome: 19
Canonical length: 446 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>Q9BQ67|GRWD1
     1  MAARKGRRRT CETGEPMEAE SGDTSSEGPA QVYLPGRGPP LREGEELVMD EEAYVLYHRA
    61  QTGAPCLSFD IVRDHLGDNR TELPLTLYLC AGTQAESAQS NRLMMLRMHN LHGTKPPPSE
   121  GSDEEEEEED EEDEEERKPQ LELAMVPHYG GINRVRVSWL GEEPVAGVWS EKGQVEVFAL
   181  RRLLQVVEEP QALAAFLRDE QAQMKPIFSF AGHMGEGFAL DWSPRVTGRL LTGDCQKNIH
   241  LWTPTDGGSW HVDQRPFVGH TRSVEDLQWS PTENTVFASC SADASIRIWD IRAAPSKACM
   301  LTTATAHDGD VNVISWSRRE PFLLSGGDDG ALKIWDLRQF KSGSPVATFK QHVAPVTSVE
   361  WHPQDSGVFA ASGADHQITQ WDLAVERDPE AGDVEADPGL ADLPQQLLFV HQGETELKEL
   421  HWHPQCPGLL VSTALSGFTI FRTISV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRWD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 26 nTPM
pancreas: 18 nTPM
esophagus: 17 nTPM
skin: 17 nTPM
liver: 15 nTPM
endometrium: 15 nTPM

Single-cell type

esophageal basal cells: 60 nCPM
migrating cytotrophoblasts: 54 nCPM
cytotrophoblasts: 49 nCPM
basal keratinocytes: 46 nCPM
extravillous trophoblasts: 42 nCPM
differentiating spermatogonia: 42 nCPM

Immune cell

MAIT T-cell: 47 nTPM
naive B-cell: 45 nTPM
memory B-cell: 45 nTPM
naive CD4 T-cell: 43 nTPM
NK-cell: 42 nTPM
gdT-cell: 42 nTPM

Brain region

thalamus: 22 nTPM
pons: 19 nTPM
midbrain: 19 nTPM
choroid plexus: 18 nTPM
white matter: 18 nTPM
cerebellum: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GRWD1.

Disease | AllUniProt

Conditions GRWD1 is implicated in, by any mechanism.

Diarrhea 14, congenital (DIAR14) MIM:621160

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 116 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Diarrhea 14, congenital
Congenital diarrhea

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: -0.75
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GRWD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRWD1 as an antibody target. Whether an autoantibody or antibody against GRWD1 could matter depends on whether native GRWD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRWD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GRWD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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