Seroatlas · Human Serome Atlas

WDR41

WD repeat-containing protein 41

Also known as: FLJ10904, WDR41_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAD4
Gene: WDR41
Ensembl: ENSG00000164253
Chromosome: 5
Canonical length: 459 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables GTPase activator activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in regulation of autophagy. Located in cytoplasm. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

459 residues, UniProt reviewed canonical sequence.

>Q9HAD4|WDR41
     1  MLRWLIGGGR EPQGLAEKSP LQTIGEEQTQ NPYTELLVLK AHHDIVRFLV QLDDYRFASA
    61  GDDGIVVVWN AQTGEKLLEL NGHTQKITAI ITFPSLESCE EKNQLILTAS ADRTVIVWDG
   121  DTTRQVQRIS CFQSTVKCLT VLQRLDVWLS GGNDLCVWNR KLDLLCKTSH LSDTGISALV
   181  EIPKNCVVAA VGKELIIFRL VAPTEGSLEW DILEVKRLLD HQDNILSLIN VNDLSFVTGS
   241  HVGELIIWDA LDWTMQAYER NFWDPSPQLD TQQEIKLCQK SNDISIHHFT CDEENVFAAV
   301  GRGLYVYSLQ MKRVIACQKT AHDSNVLHVA RLPNRQLISC SEDGSVRIWE LREKQQLAAE
   361  PVPTGFFNMW GFGRVSKQAS QPVKKQQENA TSCSLELIGD LIGHSSSVEM FLYFEDHGLV
   421  TCSADHLIIL WKNGERESGL RSLRLFQKLE ENGDLYLAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

testis: 26 nTPM
thyroid gland: 21 nTPM
skeletal muscle: 20 nTPM
pancreas: 20 nTPM
tongue: 20 nTPM
retina: 19 nTPM

Single-cell type

early spermatids: 338 nCPM
late primary spermatocytes: 232 nCPM
podocytes: 198 nCPM
oocytes: 170 nCPM
adipocytes: 167 nCPM
late spermatids: 146 nCPM

Immune cell

myeloid DC: 51 nTPM
eosinophil: 50 nTPM
non-classical monocyte: 39 nTPM
intermediate monocyte: 34 nTPM
NK-cell: 32 nTPM
classical monocyte: 29 nTPM

Brain region

white matter: 39 nTPM
medulla oblongata: 38 nTPM
basal ganglia: 36 nTPM
cerebral cortex: 36 nTPM
pons: 36 nTPM
thalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: -0.16
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
PAC1/LIS1-like, WD-40 repeat
WD40-repeat-containing domain superfamily
WD repeat-containing protein 41
WDR41

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR41 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

C9orf72

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR41 as an antibody target. Whether an autoantibody or antibody against WDR41 could matter depends on whether native WDR41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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