Seroatlas · Human Serome Atlas

WDR12

Ribosome biogenesis protein WDR12

Also known as: FLJ10881, WDR12_HUMAN, YTM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZL7
Gene
WDR12
Ensembl
ENSG00000138442
Chromosome
2
Canonical length
423 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q9GZL7|WDR12
     1  MAQLQTRFYT DNKKYAVDDV PFSIPAASEI ADLSNIINKL LKDKNEFHKH VEFDFLIKGQ
    61  FLRMPLDKHM EMENISSEEV VEIEYVEKYT APQPEQCMFH DDWISSIKGA EEWILTGSYD
   121  KTSRIWSLEG KSIMTIVGHT DVVKDVAWVK KDSLSCLLLS ASMDQTILLW EWNVERNKVK
   181  ALHCCRGHAG SVDSIAVDGS GTKFCSGSWD KMLKIWSTVP TDEEDEMEES TNRPRKKQKT
   241  EQLGLTRTPI VTLSGHMEAV SSVLWSDAEE ICSASWDHTI RVWDVESGSL KSTLTGNKVF
   301  NCISYSPLCK RLASGSTDRH IRLWDPRTKD GSLVSLSLTS HTGWVTSVKW SPTHEQQLIS
   361  GSLDNIVKLW DTRSCKAPLY DLAAHEDKVL SVDWTDTGLL LSGGADNKLY SYRYSPTTSH
   421  VGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
5.5 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 5.5 nTPM
  • kidney: 4.8 nTPM
  • liver: 3.9 nTPM
  • skeletal muscle: 3.9 nTPM
  • duodenum: 3.8 nTPM
  • heart muscle: 3.7 nTPM

Single-cell type

  • cardiomyocytes: 398 nCPM
  • adipocytes: 162 nCPM
  • myonuclei: 142 nCPM
  • epicardial cells: 132 nCPM
  • early primary spermatocytes: 110 nCPM
  • monocyte progenitors: 88 nCPM

Immune cell

  • plasmacytoid DC: 2.3 nTPM
  • myeloid DC: 2.1 nTPM
  • MAIT T-cell: 2 nTPM
  • memory B-cell: 1.8 nTPM
  • naive B-cell: 1.8 nTPM
  • intermediate monocyte: 1.7 nTPM

Brain region

  • cerebral cortex: 12 nTPM
  • hypothalamus: 11 nTPM
  • thalamus: 11 nTPM
  • pons: 10 nTPM
  • white matter: 9.8 nTPM
  • cerebellum: 9.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
0.48
DepMap mean gene effect
-1.33
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR12 as an antibody target. Whether an autoantibody or antibody against WDR12 could matter depends on whether native WDR12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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