Seroatlas · Human Serome Atlas

WDR18

WD repeat-containing protein 18

Also known as: Ipi3, WDR18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BV38
Gene
WDR18
Ensembl
ENSG00000065268
Chromosome
19
Canonical length
432 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q9BV38|WDR18
     1  MAAPMEVAVC TDSAAPMWSC IVWELHSGAN LLTYRGGQAG PRGLALLNGE YLLAAQLGKN
    61  YISAWELQRK DQLQQKIMCP GPVTCLTASP NGLYVLAGVA ESIHLWEVST GNLLVILSRH
   121  YQDVSCLQFT GDSSHFISGG KDCLVLVWSL CSVLQADPSR IPAPRHVWSH HALPITDLHC
   181  GFGGPLARVA TSSLDQTVKL WEVSSGELLL SVLFDVSIMA VTMDLAEHHM FCGGSEGSIF
   241  QVDLFTWPGQ RERSFHPEQD AGKVFKGHRN QVTCLSVSTD GSVLLSGSHD ETVRLWDVQS
   301  KQCIRTVALK GPVTNAAILL APVSMLSSDF RPSLPLPHFN KHLLGAEHGD EPRHGGLTLR
   361  LGLHQQGSEP SYLDRTEQLQ AVLCSTMEKS VLGGQDQLRV RVTELEDEVR NLRKINRDLF
   421  DFSTRFITRP AK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • liver: 32 nTPM
  • cerebellum: 31 nTPM
  • esophagus: 27 nTPM
  • kidney: 26 nTPM
  • skeletal muscle: 24 nTPM
  • skin: 22 nTPM

Single-cell type

  • extravillous trophoblasts: 206 nCPM
  • migrating cytotrophoblasts: 126 nCPM
  • esophageal basal cells: 115 nCPM
  • cytotrophoblasts: 102 nCPM
  • oocytes: 92 nCPM
  • esophageal suprabasal cells: 90 nCPM

Immune cell

  • myeloid DC: 118 nTPM
  • intermediate monocyte: 85 nTPM
  • classical monocyte: 78 nTPM
  • plasmacytoid DC: 75 nTPM
  • non-classical monocyte: 71 nTPM
  • naive B-cell: 70 nTPM

Brain region

  • medulla oblongata: 23 nTPM
  • white matter: 22 nTPM
  • thalamus: 22 nTPM
  • pons: 22 nTPM
  • cerebral cortex: 21 nTPM
  • cerebellum: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
0.99
gnomAD missense Z
0.48
DepMap mean gene effect
-1.12
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR18 as an antibody target. Whether an autoantibody or antibody against WDR18 could matter depends on whether native WDR18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WDR18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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