B-box-type zinc finger
IPR000315
Definition
This entry represents B-box-type zinc finger domains, which are around 40 residues in length. B-box zinc fingers can be divided into two groups, where types 1 and 2 B-box domains differ in their consensus sequence and in the spacing of the 7-8 zinc-binding residues. Several proteins contain both types 1 and 2 B-boxes, suggesting some level of cooperativity between these two domains. B-box domains are found in over 1500 proteins from a variety of organisms. They are found in TRIM (tripartite motif) proteins that consist of an N-terminal RING finger (originally called an A-box), followed by 1-2 B-box domains and a coiled-coil domain (also called RBCC for Ring, B-box, Coiled-Coil). TRIM proteins contain a type 2 B-box domain, and may also contain a type 1 B-box. In proteins that do not contain RING or coiled-coil domains, the B-box domain is primarily type 2. Many type 2 B-box proteins are involved in ubiquitination. Proteins containing a B-box zinc finger domain include transcription factors, ribonucleoproteins and proto-oncoproteins; for example, MID1, MID2, TRIM9, TNL, TRIM36, TRIM63, TRIFIC, NCL1 and CONSTANS-like proteins PMID:16434393. The microtubule-associated E3 ligase MID1 ([ec:6.3.2]) contains a type 1 B-box zinc finger domain. MID1 specifically binds Alpha-4, which in turn recruits the catalytic subunit of phosphatase 2A (PP2Ac). This complex is required for targeting of PP2Ac for proteasome-mediated degradation. The MID1 B-box coordinates two zinc ions and adopts a β/β/α cross-brace structure similar to that of ZZ, PHD, RING and FYVE zinc fingers [[cite:PMID:17428496], [cite:PMID:16529770]].
77 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (77 proteins: gene, accession, name)
- MEFV
- MID1
- MID2
- PML
- RNF207
- TRIM10
- TRIM11
- TRIM13
- TRIM14
- TRIM15
- TRIM16
- TRIM17
- TRIM2
- TRIM21
- TRIM22
- TRIM23
- TRIM24
- TRIM26
- TRIM27
- TRIM28
- TRIM29
- TRIM3
- TRIM31
- TRIM32
- TRIM33
- TRIM34
- TRIM35
- TRIM36
- TRIM37
- TRIM38
- TRIM39
- TRIM4
- TRIM40
- TRIM41
- TRIM42
- TRIM43
- TRIM43B
- TRIM44
- TRIM45
- TRIM46
- TRIM47
- TRIM48
- TRIM49
- TRIM49B
- TRIM49C
- TRIM49D1
- TRIM5
- TRIM50
- TRIM51
- TRIM51G
- TRIM52
- TRIM54
- TRIM55
- TRIM56
- TRIM58
- TRIM59
- TRIM6
- TRIM60
- TRIM61
- TRIM62
- TRIM63
- TRIM64
- TRIM64B
- TRIM64C
- TRIM65
- TRIM66
- TRIM67
- TRIM68
- TRIM7
- TRIM71
- TRIM72
- TRIM73
- TRIM74
- TRIM75
- TRIM77
- TRIM9
- TRIML2
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