Seroatlas · Human Serome Atlas

TRIM74

Tripartite motif-containing protein 74

Also known as: MGC45440, TRI74_HUMAN, TRIM50C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UV6
Gene: TRIM74
Ensembl: ENSG00000155428
Chromosome: 7
Canonical length: 250 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>Q86UV6|TRIM74
     1  MAWQVSLLEL EDWLQCPICL EVFKESLMLQ CGHSYCKGCL VSLSYHLDTK VRCPMCWQVV
    61  DGSSSLPNVS LAWVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH
   121  PVTPVSTVCS RMKEELAALF SELKQEQKKV DELIAKLVKN RTRIVNESDV FSWVIRREFQ
   181  ELRHPVDEEK ARCLEGIGGH TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHEF
   241  IWKFHSMASR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM74 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

stomach: 11 nTPM
testis: 6.5 nTPM
cerebellum: 4.2 nTPM
fallopian tube: 2.7 nTPM
liver: 2.7 nTPM
pancreas: 2.3 nTPM

Single-cell type

parietal cells: 34 nCPM
gastric chief cells: 4.4 nCPM
late primary spermatocytes: 1.9 nCPM
late spermatids: 1.4 nCPM
pdcs: 1.3 nCPM
granulosa cells: 0.8 nCPM

Immune cell

memory B-cell: 0.5 nTPM
basophil: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM

Brain region

cerebellum: 3.3 nTPM
white matter: 1.7 nTPM
cerebral cortex: 1.6 nTPM
medulla oblongata: 1.6 nTPM
basal ganglia: 1.3 nTPM
hypothalamus: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0.01
gnomAD missense Z: 0.65

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

innate immune response

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM74 as an antibody target. Whether an autoantibody or antibody against TRIM74 could matter depends on whether native TRIM74 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM74 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM74 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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