Seroatlas · Human Serome Atlas

TRIM52

E3 ubiquitin-protein ligase TRIM52

Also known as: RNF102, TRI52_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A61
Gene: TRIM52
Ensembl: ENSG00000183718
Chromosome: 5
Canonical length: 297 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoli,Intermediate filaments

OverviewNCBI Gene

Enables transcription coactivator activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of canonical NF-kappaB signal transduction; and protein autoubiquitination. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q96A61|TRIM52
     1  MAGYATTPSP MQTLQEEAVC AICLDYFKDP VSISCGHNFC RGCVTQLWSK EDEEDQNEEE
    61  DEWEEEEDEE AVGAMDGWDG SIREVLYRGN ADEELFQDQD DDELWLGDSG ITNWDNVDYM
   121  WDEEEEEEEE DQDYYLGGLR PDLRIDVYRE EEILEAYDED EDEELYPDIH PPPSLPLPGQ
   181  FTCPQCRKSF TRRSFRPNLQ LANMVQIIRQ MCPTPYRGNR SNDQGMCFKH QEALKLFCEV
   241  DKEAICVVCR ESRSHKQHSV LPLEEVVQEY QEIKLETTLV GILQIEQESI HSKAYNQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

retina: 22 nTPM
lymph node: 15 nTPM
spleen: 13 nTPM
thymus: 12 nTPM
tonsil: 11 nTPM
skin: 11 nTPM

Single-cell type

cardiomyocytes: 56 nCPM
adipocytes: 49 nCPM
early spermatids: 37 nCPM
myonuclei: 34 nCPM
innate lymphoid cells: 33 nCPM
adrenal medulla cells: 32 nCPM

Immune cell

naive CD4 T-cell: 17 nTPM
basophil: 16 nTPM
MAIT T-cell: 14 nTPM
memory CD8 T-cell: 14 nTPM
naive CD8 T-cell: 13 nTPM
memory CD4 T-cell: 13 nTPM

Brain region

cerebellum: 28 nTPM
white matter: 22 nTPM
cerebral cortex: 22 nTPM
choroid plexus: 22 nTPM
pons: 21 nTPM
thalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM52 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM41

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM52 as an antibody target. Whether an autoantibody or antibody against TRIM52 could matter depends on whether native TRIM52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM52 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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