Seroatlas · Human Serome Atlas

TRIM13

E3 ubiquitin-protein ligase TRIM13

Also known as: DLEU5, Leu5, RFP2, RNF77, TRI13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60858
Gene
TRIM13
Ensembl
ENSG00000204977
Chromosome
13
Canonical length
407 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>O60858|TRIM13
     1  MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG SVRNSLWRPA PFKCPTCRKE
    61  TSATGINSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR
   121  GEHTKHVFCS IEDAYAQERD AFESLFQSFE TWRRGDALSR LDTLETSKRK SLQLLTKDSD
   181  KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQAYDPEIN KLNTILQEQR MAFNIAEAFK
   241  DVSEPIVFLQ QMQEFREKIK VIKETPLPPS NLPASPLMKN FDTSQWEDIK LVDVDKLSLP
   301  QDTGTFISKI PWSFYKLFLL ILLLGLVIVF GPTMFLEWSL FDDLATWKGC LSNFSSYLTK
   361  TADFIEQSVF YWEQVTDGFF IFNERFKNFT LVVLNNVAEF VCKYKLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • testis: 74 nTPM
  • bone marrow: 62 nTPM
  • skin: 26 nTPM
  • esophagus: 25 nTPM
  • skeletal muscle: 24 nTPM
  • tongue: 23 nTPM

Single-cell type

  • late primary spermatocytes: 682 nCPM
  • early spermatids: 498 nCPM
  • epicardial cells: 355 nCPM
  • myonuclei: 328 nCPM
  • fibro-adipogenic progenitors: 146 nCPM
  • esophageal apical cells: 144 nCPM

Immune cell

  • memory B-cell: 47 nTPM
  • naive B-cell: 46 nTPM
  • neutrophil: 35 nTPM
  • plasmacytoid DC: 35 nTPM
  • T-reg: 30 nTPM
  • eosinophil: 29 nTPM

Brain region

  • white matter: 51 nTPM
  • cerebellum: 48 nTPM
  • basal ganglia: 40 nTPM
  • cerebral cortex: 36 nTPM
  • medulla oblongata: 35 nTPM
  • thalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.64
gnomAD missense Z
0.94
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM13 as an antibody target. Whether an autoantibody or antibody against TRIM13 could matter depends on whether native TRIM13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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