Seroatlas · Human Serome Atlas

TRIM42

Tripartite motif-containing protein 42

Also known as: FLJ40097, PPP1R40, T4A1, TRI42_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWZ5
Gene: TRIM42
Ensembl: ENSG00000155890
Chromosome: 3
Canonical length: 723 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

723 residues, UniProt reviewed canonical sequence.

>Q8IWZ5|TRIM42
     1  METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC QFCHCTCSES
    61  PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI ITFHKGRLRS IHTSSKTALR
   121  TGSSDTQVDE VKSIPANSHL VNHLNCPMCS RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT
   181  ENFFILICPV CDRSHCMPYS NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV
   241  CRNKRIAYKR CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE
   301  YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAVRYE IDNDLMEFNI
   361  LKNSFKADKE AKRKEIRNGF LKLRSILQEK EKIIMEQIEN LEVSRQKEIE KYVYVTTMKV
   421  NEMDGLIAYS KEALKETGQV AFLQSAKILV DQIEDGIQTT YRPDPQLRLH SINYVPLDFV
   481  ELSSAIHELF PTGPKKVRSS GDSLPSPYPV HSETMIARKV TFSTHSLGNQ HIYQRSSSML
   541  SFSNTDKKAK VGLEACGRAQ SATPAKPTDG LYTYWSAGAD SQSVQNSSSF HNWYSFNDGS
   601  VKTPGPIVIY QTLVYPRAAK VYWTCPAEDV DSFEMEFYEV ITSPPNNVQM ELCGQIRDIM
   661  QQNLELHNLT PNTEYVFKVR AINDNGPGQW SDICKVVTPD GHGKNRAKWG LLKNIQSALQ
   721  KHF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

testis: 16 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 320 nCPM
late spermatids: 211 nCPM
late primary spermatocytes: 17 nCPM
oocytes: 14 nCPM
adipocytes: 3.8 nCPM
leydig cells: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.8 nTPM
midbrain: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein ubiquitination

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM42 as an antibody target. Whether an autoantibody or antibody against TRIM42 could matter depends on whether native TRIM42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...