Seroatlas · Human Serome Atlas

TRIM59

Tripartite motif-containing protein 59

Also known as: Mrf1, RNF104, TRI59_HUMAN, TRIM57, TSBF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWR1
Gene: TRIM59
Ensembl: ENSG00000213186
Chromosome: 3
Canonical length: 403 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>Q8IWR1|TRIM59
     1  MHNFEEELTC PICYSIFEDP RVLPCSHTFC RNCLENILQA SGNFYIWRPL RIPLKCPNCR
    61  SITEIAPTGI ESLPVNFALR AIIEKYQQED HPDIVTCPEH YRQPLNVYCL LDKKLVCGHC
   121  LTIGQHHGHP IDDLQSAYLK EKDTPQKLLE QLTDTHWTDL THLIEKLKEQ KSHSEKMIQG
   181  DKEAVLQYFK ELNDTLEQKK KSFLTALCDV GNLINQEYTP QIERMKEIRE QQLELMALTI
   241  SLQEESPLKF LEKVDDVRQH VQILKQRPLP EVQPVEIYPR VSKILKEEWS RTEIGQIKNV
   301  LIPKMKISPK RMSCSWPGKD EKEVEFLKIL NIVVVTLISV ILMSILFFNQ HIITFLSEIT
   361  LIWFSEASLS VYQSLSNSLH KVKNILCHIF YLLKEFVWKI VSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM59 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 16 nTPM
thymus: 13 nTPM
tonsil: 11 nTPM
lymph node: 11 nTPM
cerebral cortex: 10 nTPM
spinal cord: 9.3 nTPM

Single-cell type

oligodendrocytes: 390 nCPM
hepatic stellate cells: 19 nCPM
endometrial secretory cells: 19 nCPM
epididymal clear cells: 16 nCPM
cone photoreceptor cells: 10 nCPM
thymocytes: 10 nCPM

Immune cell

basophil: 29 nTPM
T-reg: 22 nTPM
memory CD4 T-cell: 18 nTPM
memory CD8 T-cell: 15 nTPM
naive CD8 T-cell: 15 nTPM
MAIT T-cell: 13 nTPM

Brain region

white matter: 151 nTPM
basal ganglia: 93 nTPM
cerebral cortex: 66 nTPM
thalamus: 65 nTPM
midbrain: 63 nTPM
medulla oblongata: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: 0.19
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM59 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM59 as an antibody target. Whether an autoantibody or antibody against TRIM59 could matter depends on whether native TRIM59 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM59 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM59 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...